2,3-二氢-1H-茚-2-甲腈合成路线 （共 5 条）
反应条件
in acetonitrile T=55°C; 5 h;
参考文献
ABBOTT GMBH and CO. KG
Patent: WO2006/40180 A1, 2006 ;
Location in patent: Page/Page column 106 ;
WO 2006/040180 A1
反应条件
in N,N-dimethyl-formamide T=90°C; 3 h;
参考文献
Ksander; DeJesus; Yuan; Fink; Moskal; Carlson; Kukkola; Bilci; Wallace; Neubert; Feldman; Mogelesky; Poirier; Jeune; Steele; Wasvery; Stephan; Cahill; Webb; Navarrete; Lee; Gibson; Alexander; Sharif; Hospattankar
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4677 - 4687
反应条件
1: 90 percent / iPr2NEt; DMAP / CH2Cl2 / 16.5 h 2: 49 percent / dimethylformamide / 3 h / 90 °C View Scheme
参考文献
Ksander; DeJesus; Yuan; Fink; Moskal; Carlson; Kukkola; Bilci; Wallace; Neubert; Feldman; Mogelesky; Poirier; Jeune; Steele; Wasvery; Stephan; Cahill; Webb; Navarrete; Lee; Gibson; Alexander; Sharif; Hospattankar
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4677 - 4687
反应条件
hydrogenchloride in 1,4-dioxane; water T=60 - 70°C; 41 h;
参考文献
AUCKLAND UNISERVICES LIMITED
Patent: WO2006/104406 A1, 2006 ;
Location in patent: Page/Page column 112 ;
反应条件
lithium aluminium tetrahydride in diethyl ether
3 h;
参考文献
Ksander; DeJesus; Yuan; Fink; Moskal; Carlson; Kukkola; Bilci; Wallace; Neubert; Feldman; Mogelesky; Poirier; Jeune; Steele; Wasvery; Stephan; Cahill; Webb; Navarrete; Lee; Gibson; Alexander; Sharif; Hospattankar
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4677 - 4687
