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63148-62-9
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471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
264608-17-5
合成路线
（共 9 条）
264608-14-2
+
73963-98-1
→
反应条件
264608-17-5
+
264608-18-6
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=100°C; 6 h;
参考文献
Pfizer Inc
Patent: US6900309 B1, 2005 ;
Location in patent: Page/Page column 37-38 ;
264608-14-2
→
反应条件
264608-17-5
反应条件
triethylamine; tetrakis (triphenylphosphine) palladium (0) in N,N-dimethyl-formamide
参考文献
Mantell, Simon John; Monaghan, Sandra Marina; Stephenson, Peter Thomas
Patent: US2001/20089 A1, 2001 ;
→
反应条件
264608-17-5
反应条件
in DMF (N,N-dimethyl-formamide) T=120°C; 25 h; Heating / reflux;
参考文献
Pfizer Inc
Patent: US6350735 B1, 2002 ;
Location in patent: Page column 23 ;
264608-16-4
→
反应条件
264608-17-5
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Pfizer Inc
Patent: US6326359 B1, 2001 ;
557-21-1
氰化锌
+
264608-14-2
→
反应条件
264608-17-5
+
264608-18-6
+
884654-08-4
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in N,N-dimethyl-formamide T=80 - 82°C; P=7500.75 Torr; 21 h; AutoclaveInert atmosphereLarge scale;
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
264608-16-4
+
151-50-8
氰化钾
→
反应条件
264608-17-5
反应条件
1: in N,N-dimethyl-formamide T=120°C; 24 h; 2: in water T=20°C; 1 h; Product distribution / selectivity;
参考文献
Pfizer Inc
Patent: US6900309 B1, 2005 ;
Location in patent: Page/Page column 37 ;
110-87-2
3,4-二氢-2H-吡喃
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反应条件
264608-17-5
反应条件
1: toluene-4-sulfonic acid / ethyl acetate / 2 h / 50 - 62 °C / |Inert atmosphere; |Large scale 2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale 3: triethylamine; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 80 - 82 °C / 7500.75 Torr / |Autoclave; |Inert atmosphere; |Large scale View Scheme
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
20419-68-5
2,6-二氯-9-(四氢-2H-吡喃-2-基)-9h-嘌呤
→
反应条件
264608-17-5
+
264608-18-6
反应条件
1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale 2: triethylamine; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 80 - 82 °C / 7500.75 Torr / |Autoclave; |Inert atmosphere; |Large scale View Scheme
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
5451-40-1
2,6-二氯嘌呤
→
反应条件
264608-17-5
+
264608-18-6
反应条件
1: toluene-4-sulfonic acid / ethyl acetate / 2 h / 50 - 62 °C / |Inert atmosphere; |Large scale 2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale 3: triethylamine; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 80 - 82 °C / 7500.75 Torr / |Autoclave; |Inert atmosphere; |Large scale View Scheme
参考文献
Challenger, Stephen; Dessi, Yann; Fox, Darrell E.; Hesmondhalgh, Lynsey C.; Pascal, Pierre; Pettman, Alan J.; Smith, Julian D.
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 575 - 583
