6-(叔丁氧基羰基)-5,6,7,8-四氢吡啶并[3,4-b]吡嗪-7-羧酸合成路线 （共 5 条）
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 4 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=3;
参考文献
Hashimoto, Koji; Higashiyama, Shigeki; Yoshino, Kohichiro; Yoshiizumi, Kazuya; Yamamoto, Minoru
Patent: US2003/229113 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 72 h;
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
1: 44 percent / N-chlorosuccimide; benzoyl peroxide / CCl4 / 21 h / Heating 2: 60 percent / Cs2CO3 / acetonitrile / 5 h / Heating 3: 6N HCl / 1 h / Heating 4: 44 percent / aq. NaOH / dioxane / 72 h / 20 °C View Scheme
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
1: 60 percent / Cs2CO3 / acetonitrile / 5 h / Heating 2: 6N HCl / 1 h / Heating 3: 44 percent / aq. NaOH / dioxane / 72 h / 20 °C View Scheme
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
1: 6N HCl / 1 h / Heating 2: 44 percent / aq. NaOH / dioxane / 72 h / 20 °C View Scheme
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
