6-乙酰基-5,6-二氢吡啶并[3,4-b]吡嗪-7,7(8h)-二羧酸二乙酯合成路线 （共 5 条）
反应条件
caesium carbonate in acetonitrile 5 h; Heating;
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
1: 44 percent / N-chlorosuccimide; benzoyl peroxide / CCl4 / 21 h / Heating 2: 60 percent / Cs2CO3 / acetonitrile / 5 h / Heating View Scheme
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
hydrogenchloride in water T=100°C; 3 h;
参考文献
Hashimoto, Koji; Higashiyama, Shigeki; Yoshino, Kohichiro; Yoshiizumi, Kazuya; Yamamoto, Minoru
Patent: US2003/229113 A1, 2003 ;
Location in patent: Page 20 ;
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
反应条件
1: 6N HCl / 1 h / Heating 2: 44 percent / aq. NaOH / dioxane / 72 h / 20 °C View Scheme
参考文献
Yoshiizumi, Kazuya; Yamamoto, Minoru; Miyasaka, Tomohiro; Ito, Yasuko; Kumihara, Hiroshi; Sawa, Masaaki; Kiyoi, Takao; Yamamoto, Takeshi; Nakajima, Fumio; Hirayama, Ryoichi; Kondo, Hirosato; Ishibushi, Etsuko; Ohmoto, Hiroshi; Inoue, Yoshimasa; Yoshino, Kohichiro
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 433 - 450
