2-(2-硝基苯基)丙二酸二甲酯合成路线 （共 8 条）
反应条件
1: malonic acid dimethyl ester With potassium tert-butylate in N,N-dimethyl-formamide T=90°C; 0.166667 h; 2: 2-fluoro-1-nitrobenzene in N,N-dimethyl-formamide T=20 - 90°C; 2 h;
参考文献
Yoshida, Masahiro; Maeyama, Yohei; Shishido, Kozo
Tetrahedron, 2012 , vol. 68, # 48 p. 9962 - 9972,11
反应条件
sodium hydride in tetrahydrofuran T=-78°C; Inert atmosphere;
参考文献
Sriramurthy, Vardhineedi; Kwon, Ohyun
Organic Letters, 2010 , vol. 12, # 5 p. 1084 - 1087
反应条件
in N,N-dimethyl-formamide 0.065 h; microwave irradiation;
参考文献
Comer, Eamon; Organ, Michael G.
Journal of the American Chemical Society, 2005 , vol. 127, # 22 p. 8160 - 8167
反应条件
hydrogenchloride; water in water
参考文献
Kammasud, Naparat; Boonyarat, Chantana; Sanphanya, Kingkan; Utsintong, Maleeruk; Tsunoda, Satoshi; Sakurai, Hiroaki; Saiki, Ikuo; Andre, Isabelle; Grierson, David S.; Vajragupta, Opa
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 745 - 750
反应条件
potassium carbonate in water T=60°C;
参考文献
Selvakumar; Azhagan, A.Malar; Srinivas; Krishna, G.Gopi
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9175 - 9178
反应条件
1: 72 percent / NaH / dimethylformamide / 20 °C
2: 85 percent / NaCl / dimethylsulfoxide / 155 °C
3: 90 percent / H2 / Pd/C / methanol
View Scheme
参考文献
Selvakumar; Reddy, B. Yadi; Azhagan, A. Malar; Khera, Manoj Kumar; Babu, J. Moses; Iqbal, Javed
Tetrahedron Letters, 2003 , vol. 44, # 37 p. 7065 - 7069
反应条件
1: 75 percent / K2CO3 / H2O / 2 h / 60 °C
2: 86 percent / 3 Angstroem molecular sieves; paraformaldehyde / toluene / Heating
3: 84 percent / H2 / Pd/C / methanol
View Scheme
参考文献
Selvakumar; Azhagan, A.Malar; Srinivas; Krishna, G.Gopi
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9175 - 9178
反应条件
1: 72 percent / NaH / tetrahydrofuran / 20 °C
2: 58 percent / NaCl / dimethylsulfoxide / 110 °C
3: H2 / Pd/C / tetrahydrofuran
View Scheme
参考文献
Selvakumar; Yadi Reddy; Sunil Kumar; Iqbal, Javed
Tetrahedron Letters, 2001 , vol. 42, # 47 p. 8395 - 8398
