3,3-二甲基-2,3-二氢-1H-茚-1-酮合成路线 （共 47 条）
反应条件
1: diethyl ether View Scheme
参考文献
Halford,J.O. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1898 - 1901
参考文献
Gelin,R.; Chantegrel,B.
Bulletin de la Societe Chimique de France, 1971 , p. 2527 - 2544
反应条件
1: diethyl ether 3: Raney nickel; methanol / Hydrogenation View Scheme
参考文献
Gelin,R.; Chantegrel,B.
Bulletin de la Societe Chimique de France, 1971 , p. 2527 - 2544
反应条件
1: 20 °C 2: glacial acetic acid; H2SO4 3: chromium (VI)-oxide; acetic acid View Scheme
参考文献
Flammang; Wermuth
European Journal of Medicinal Chemistry, 1976 , vol. 11, # 1 p. 83 - 88
反应条件
(i) , (ii) (dehydration), (iii) CrO3, AcOH; Multistep reaction;
参考文献
Newman,M.S. et al.
Journal of the American Chemical Society, 1968 , vol. 90, p. 747 - 750
反应条件
1: sodium hydride / benzene / 15 h / Ambient temperature 2: aq. sodium hydroxide, aq. hydrogen peroxide / methanol / 1.) room temperature, 15 min, 2.) reflux, 30 min 3: aq. HClO4 / acetonitrile / 28.5 °C View Scheme
参考文献
Hillery, Paul S.; Cohen, Louis A.
Journal of the American Chemical Society, 1983 , vol. 105, # 9 p. 2760 - 2770
反应条件
1: KNO3, H2SO4 / 0 °C 2: 1.) H2, 2.) NaNO2, HCl, 3.) H2SO4, H2O / 1.) PtO / 2) 0 deg C; 3) heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 102, # 17 p. 5618 - 5626
反应条件
1: KNO3, H2SO4 / 0 °C
2: 1.) H2, 2.) NaNO2, HCl, 3.) H2SO4, H2O / 1.) PtO / 2) 0 deg C; 3) heating
3: K2CO3 / acetone
View Scheme
参考文献
Bott, Garry; Field, Leslie D.; Sternhell, Sever
Journal of the American Chemical Society, 1980 , vol. 102, # 17 p. 5618 - 5626
反应条件
1: 97 percent / LiAlH4 / diethyl ether / Heating
2: 84 percent / p-toluenesulfonic acid / 80 - 100 °C
View Scheme
参考文献
Bingham,A.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1970 , p. 1879 - 1883
反应条件
bromine; aluminium trichloride
参考文献
Bristol-Myers Squibb Co.
Patent: US5648385 A1, 1997 ;
