1.1: 97 percent / Et3N / CH2Cl2 / 3 h / 0 - 20 °C 2.1: 70 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 0 °C 3.1: 84 percent / TFA; anisole / 24 h / Heating 4.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 4.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 5.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 6.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1.1: 84 percent / TFA; anisole / 24 h / Heating 2.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 2.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 3.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 4.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 2: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1.1: 70 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 0 °C 2.1: 84 percent / TFA; anisole / 24 h / Heating 3.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 3.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 4.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 5.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 1.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 2.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 3.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1.1: toluene / 3 h / Heating 2.1: 5.22 g / NaBH4 / methanol / 2 h / 20 °C 3.1: 97 percent / Et3N / CH2Cl2 / 3 h / 0 - 20 °C 4.1: 70 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 0 °C 5.1: 84 percent / TFA; anisole / 24 h / Heating 6.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 6.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 7.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 8.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1.1: nBuLi / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C 1.2: 80 percent / tetrahydrofuran; hexane / 2.17 h / -78 - 20 °C 2.1: 62 percent / tBuLi / pentane; tetrahydrofuran / 0.5 h / -100 - 20 °C 3.1: 92 percent / triethylsilyl hydride; TFA / CH2Cl2 / 2 h / 20 °C View Scheme

1: 96 percent / n-BuLi / tetrahydrofuran / 4 h / -78 °C 2: 99 percent / NaBH4 / trifluoroacetic acid / 1 h / 0 - 20 °C View Scheme

1: 100 percent / magnesium sulphate / CH2Cl2 / 16 h / 20 °C 2: 89 percent / trifluoroacetic acid / benzene / 12 h / Heating 3: 52 percent / Pd(OAc)2; PPh3; Et3N / toluene / 16 h / 110 °C View Scheme

1: triethylamine / acetone / 96 h / Ambient temperature 2: trifluoroacetic acid / CH2Cl2 / Ambient temperature View Scheme