2-氨基-6,7-二氢噻唑并[5,4-c]吡啶-4(5H)-酮合成路线 （共 5 条）
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 0.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; MACDONALD, Gregor, James; TRABANCO-SUAREZ, Andres, Avelino; CONDE-CEIDE, Susana; TRESADERN, Gary, John; BARTOLOME-NEBREDA, Jose, Manuel; PASTOR-FERNANDEZ, Joaquin
Patent: WO2011/73339 A1, 2011 ;
Location in patent: Page/Page column 42 ;
WO 2011/073339 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=150°C; 12 h;
参考文献
Packiarajan, Mathivanan; Grenon, Michel; Zorn, Samuel; Hopper, Allen T.; White, Andrew D.; Chandrasena, Gamini; Pu, Xiaosui; Brodbeck, Robbin M.; Robichaud, Albert J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 14 p. 4037 - 4043
反应条件
1: N-bromosuccinmide / tetrachloromethane / 2 h / 10 - 15 °C 2: sodium hydrogencarbonate / ethanol / 2.5 h / 80 °C 3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C View Scheme
参考文献
Packiarajan, Mathivanan; Grenon, Michel; Zorn, Samuel; Hopper, Allen T.; White, Andrew D.; Chandrasena, Gamini; Pu, Xiaosui; Brodbeck, Robbin M.; Robichaud, Albert J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 14 p. 4037 - 4043
反应条件
1: sodium hydrogencarbonate / ethanol / 2.5 h / 80 °C 2: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; MACDONALD, Gregor, James; TRABANCO-SUAREZ, Andres, Avelino; CONDE-CEIDE, Susana; TRESADERN, Gary, John; BARTOLOME-NEBREDA, Jose, Manuel; PASTOR-FERNANDEZ, Joaquin
Patent: WO2011/73339 A1, 2011 ;
WO 2011/073339 A1
反应条件
copper(ll) bromide; isopentyl nitrite in acetonitrile T=20°C; 1.5 h;
参考文献
JANSSEN PHARMACEUTICA NV; MACDONALD, Gregor, James; TRABANCO-SUAREZ, Andres, Avelino; CONDE-CEIDE, Susana; TRESADERN, Gary, John; BARTOLOME-NEBREDA, Jose, Manuel; PASTOR-FERNANDEZ, Joaquin
Patent: WO2011/73339 A1, 2011 ;
Location in patent: Page/Page column 43 ;
WO 2011/073339 A1
