N-苄氧羰基-L-谷氨酰胺合成路线 （共 50 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=0°C; 3.5 h;
参考文献
Kuwahara, Masayasu; Hanawa, Kazuo; Ohsawa, Kazuomi; Kitagata, Rina; Ozaki, Hiroaki; Sawai, Hiroaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2518 - 2526
反应条件
n-ethyl morpholine; hexamethylphosphorous triamide dichloride in dichloromethane 1) 0 deg C, 2 h, 2) overnight, r.t.; Title compound not separated from byproducts;
参考文献
Appel, Rolf; Glaesel, Ursula
Chemische Berichte, 1980 , vol. 113, # 11 p. 3511 - 3516
反应条件
1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: AcOH / Heating 4: H2 / 10 percent Pd/C / acetone / 2585.74 - 3102.89 Torr View Scheme
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
反应条件
1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: AcOH / Heating View Scheme
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
参考文献
Koenig,W.; Geiger,R.
Chemische Berichte, 1970 , vol. 103, p. 2041 - 2051
反应条件
1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: Et3N / dimethylformamide / 80 °C View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2013/5229 A1, 2013 ;
反应条件
n-ethyl morpholine; hexamethylphosphorous triamide dichloride in N,N-dimethyl-formamide T=-20°C;
参考文献
Appel, Rolf; Glaesel, Ursula
Chemische Berichte, 1980 , vol. 113, # 11 p. 3511 - 3516
反应条件
(i) DMF, (ii) /BRN= 2061271/, Et3N; Multistep reaction;
参考文献
Gagnon, Paul; Huang, Xicai; Therrien, Eric; Keillor, Jeffrey W.
Tetrahedron Letters, 2002 , vol. 43, # 43 p. 7717 - 7719
参考文献
Sakakibara,S.; Inukai,N.
Bulletin of the Chemical Society of Japan, 1964 , vol. 37, p. 1231 - 1232
反应条件
1: Et3N; DMAP / acetonitrile / 0.75 h / 20 °C 2: Et3N / acetonitrile; H2O / 1.67 h / 20 °C View Scheme
参考文献
Beyerman,H.C.; Bontekoe,J.S.
Recueil des Travaux Chimiques des Pays-Bas, 1964 , vol. 83, p. 255 - 275
