N-苄氧羰基-L-谷氨酰胺合成路线 （共 50 条）
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Abe, Masatoshi; Akiyama, Tetsuo; Umezawa, Yoji; Yamamoto, Keiichiro; Nagai, Masashi; Yamazaki, Hiroko; Ichikawa, Yuh-Ichiro; Muraoka, Yasuhiko
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 785 - 797
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane
T=-20 - 20°C; further amount of alcohol; Product distribution;
参考文献
Kim; Patel
Tetrahedron Letters, 1994 , vol. 35, # 31 p. 5603 - 5606
反应条件
diethyl ether; ethanol
参考文献
Sondheimer; Holley
Journal of the American Chemical Society, 1954 , vol. 76, p. 2467,2469
反应条件
ammonium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine
1.) -20 deg C, 2.) -20 deg C -> r.t., 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kim; Patel
Tetrahedron Letters, 1994 , vol. 35, # 31 p. 5603 - 5606
反应条件
toluene-4-sulfonic acid
参考文献
Taschner,E.; Wasielewski,C.
Justus Liebigs Annalen der Chemie, 1961 , vol. 640, p. 142 - 144
反应条件
1: chlorocarbonic acid ethyl ester; triethylamine; THF / Reagens 4: H2O
2: DMF; N2H4+H2O
3: acetic acid; NaNO2; aqueous HCl
4: DMF
View Scheme
参考文献
Rudinger et al.
Collection of Czechoslovak Chemical Communications, 1956 , vol. 21, p. 202,207
反应条件
(i) HgO, PE, (ii) /BRN= 2061271/, DMF; Multistep reaction;
参考文献
Sondheimer,E.; Semeraro,R.J.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1847 - 1849
反应条件
1: CDI / tetrahydrofuran / Heating
2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr
3: AcOH / Heating
View Scheme
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
反应条件
1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / 20 °C
1.2: 97 h / Inert atmosphere
2.1: tert.-butylnitrite / acetonitrile / 2 h / Inert atmosphere; Reflux
View Scheme
参考文献
PERSCITUS BIOSCIENCES, LLC
Patent: WO2008/119032 A1, 2008 ;
反应条件
1: Et3N / tetrahydrofuran
2: dimethylformamide; tetrahydrofuran / 10 h / -15 - 20 °C
3: Pd, H2O / 1 h
View Scheme
参考文献
Sivanandaiah, K. M.; Rangaraju, N. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 787 - 792
