2,4,5-三甲氧基苯胺合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; P=775.722 Torr; 3 h;
参考文献
Downer, Nadale K.; Jackson, Yvette A.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 20 p. 3039 - 3043
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate P=1551.49 Torr; 6 h;
参考文献
Maiti, Arup; Reddy, P. V. Narasimha; Sturdy, Megan; Marler, Laura; Pegan, Scott D.; Mesecar, Andrew D.; Pezzuto, John M.; Cushman, Mark
Journal of Medicinal Chemistry, 2009 , vol. 52, # 7 p. 1873 - 1884
反应条件
potassium hydroxide in ethanol Hydrolysis; 4.75 h;
参考文献
Raposo, M. Manuela M.; Pereira, Alexandra M. B.; Oliveira-Campos, Ana M. F.; Shannon, Patrick V. R.
Journal of Chemical Research, Miniprint, 2000 , # 4 p. 528 - 558
反应条件
1: nitric acid / water / -10 °C 2: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 15 h / 20 °C / Inert atmosphere View Scheme
参考文献
Donohoe, Timothy J.; Jones, Christopher R.; Kornahrens, Anne F.; Barbosa, Luiz C. A.; Walport, Louise J.; Tatton, Matthew R.; O'Hagan, Michael; Rathi, Akshat H.; Baker, David B.
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12338 - 12350
反应条件
1: 68 percent / Cu2O; K2CO3 / 29 h / 190 - 200 °C 2: 1 percent / aq. KOH / ethanol / 4.75 h View Scheme
参考文献
Raposo, M. Manuela M.; Pereira, Alexandra M. B.; Oliveira-Campos, Ana M. F.; Shannon, Patrick V. R.
Journal of Chemical Research, Miniprint, 2000 , # 4 p. 528 - 558
参考文献
Schueler
Archiv der Pharmazie (Weinheim, Germany), 1907 , vol. 245, p. 267,271
反应条件
1: 50 percent- nitric acid / 5 °C 2: sulfurous acid View Scheme
参考文献
Schueler
Archiv der Pharmazie (Weinheim, Germany), 1907 , vol. 245, p. 267,271
反应条件
1: 51 percent / 6N HCl / 0.5 h / Heating 2: 41 percent / CAN, pyridine-2,6-dicarboxylic acid N-oxide / acetonitrile; H2O / 0.5 h / 0 - 5 °C View Scheme
参考文献
Kitahara, Yoshiyasu; Nagaoka, Yasuo; Matsumura, Tamaki; Kubo, Akinori
Heterocycles, 1994 , vol. 38, # 3 p. 659 - 678
反应条件
hydrogenchloride; sodium nitrite in water
参考文献
Choay S.A.
Patent: US4714700 A1, 1987 ;
反应条件
1: Erhitzen des Reaktionsprodukts in Paraffinoel auf 240grad
2: aqueous HBr / Behandeln des Reaktionsprodukts mit K3<Fe(CN)6> und NaHCO3 in H2O
View Scheme
参考文献
Butenandt et al.
Justus Liebigs Annalen der Chemie, 1954 , vol. 590, p. 75,79
