(4-溴苯甲酰)乙酸乙酯合成路线 （共 15 条）
反应条件
1: carbonic acid diethyl ester With sodium hydride in toluene; mineral oil T=0 - 20°C; 2 h; 2: para-bromoacetophenone in toluene; mineral oil Reflux;
参考文献
PRESIDIO PHARMACEUTICALS, INC.; ZHONG, Min; LI, Leping
Patent: WO2012/58125 A1, 2012 ;
Location in patent: Page/Page column 147 ;
WO 2012/058125 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride in neat (no solvent) T=20°C; 5 h;
参考文献
Chen, Shufeng; Yuan, Fang; Zhao, Haiying; Li, Baoguo
RSC Advances, 2013 , vol. 3, # 31 p. 12616 - 12620
反应条件
[CpFe(CO)2(THF)][BF4] in dichloromethane T=0°C; 24 h;
参考文献
Dudley, Matthew E.; Morshed, Monzur; Brennan, Courtney L.; Islam, M. Shahidul; Ahmad, M. Syarhabil; Atuu, Mary-Rose; Branstetter, Bryan; Hossain, M. Mahmun
Journal of Organic Chemistry, 2004 , vol. 69, # 22 p. 7599 - 7608
反应条件
acetic acid in ice-water; carbonic acid diethyl ester
参考文献
Hoffmann-La Roche Inc.
Patent: US5763450 A1, 1998 ;
反应条件
molybdenium(VI) dioxodichloride in dichloromethane T=20°C; 3 h;
参考文献
Jeyakumar, Kandasamy; Chand, Dillip Kumar
Synthesis, 2008 , # 11 p. 1685 - 1687
反应条件
samarium; iodine in tetrahydrofuran 1 h; Heating;
参考文献
Zou, Xuefei; Jia, Xiaofei; Wang, Xiaoxia; Xie, Guanqun
Synthetic Communications, 2007 , vol. 37, # 10 p. 1617 - 1625
反应条件
1: ethyl methyl carbonate With sodium hydride T=20°C; Inert atmosphere; 2: para-bromoacetophenone 4 h; Inert atmosphereReflux;
参考文献
Balamurugan, Rengarajan; Manojveer, Seetharaman
Chemical Communications, 2011 , vol. 47, # 39 p. 11143 - 11145
反应条件
1.1: 78 percent / DBU / H2O / 24 h / 20 °C 2.1: triethylamine / CH2Cl2 / 0.08 h / 0 °C 2.2: CH2Cl2 / 2 h / 0 - 20 °C 3.1: Rh2(OAc)4 / CH2Cl2 / 20 °C 3.2: 12 percent / silica gel View Scheme
参考文献
Chen, Shufeng; Yuan, Fang; Zhao, Haiying; Li, Baoguo
RSC Advances, 2013 , vol. 3, # 31 p. 12616 - 12620
反应条件
1.1: sodium hydride / ethanol / 40 - 50 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: sodium carbonate / water / 12 - 15 h / Reflux View Scheme
参考文献
Streuff, Jan; Feurer, Markus; Bichovski, Plamen; Frey, Georg; Gellrich, Urs
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8661 - 8664
反应条件
ytterbium trichloride in ethanol T=50°C; 24 h;
参考文献
Cai, Lijian; Ji, Xiaofeng; Yao, Zhigang; Xu, Fan; Shen, Qi
Chinese Journal of Chemistry, 2011 , vol. 29, # 9 p. 1880 - 1886
