6-乙酰基-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 13 条）
反应条件
1: 3,4-dihydro-2H-1,4-benzoxazin-3(4H)-one With AlCl3, aluminium chloride in dichloromethane Friedel-Crafts Acylation; 0.5 h; Cooling with ice; 2: acetic anhydride in dichloromethane 5 h; Reflux;
参考文献
Zhou, Xue-Wen; Ma, Han-Lin; Zhang, Xuan; Jing, Shi-Yao; Miao, Jun-Ying; Zhao, Bao-Xiang
European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 95 - 101
反应条件
AlCl3, aluminium chloride in 1,2-dichloro-ethane
参考文献
Hasui, Tomoaki; Ohra, Taiichi; Ohyabu, Norio; Asano, Kouhei; Matsui, Hideki; Mizukami, Atsushi; Habuka, Noriyuki; Sogabe, Satoshi; Endo, Satoshi; Siedem, Christopher S.; Tang, Tony P.; Gauthier, Cassandra; De Meese, Lisa A.; Boyd, Steven A.; Fukumoto, Shoji
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 19 p. 5983 - 5994
反应条件
sodium sulfite in pyridine; water
参考文献
Geng, Bolin; Comita-Prevoir, Janelle; Eyermann, Charles J.; Reck, Folkert; Fisher, Stewart
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5432 - 5435
反应条件
1: caesium carbonate / N,N-dimethyl-formamide 2: iron; acetic acid View Scheme
参考文献
Gangloff, Anthony R.; Brown, Jason; De Jong, Ron; Dougan, Douglas R.; Grimshaw, Charles E.; Hixon, Mark; Jennings, Andy; Kamran, Ruhi; Kiryanov, Andre; O'Connell, Shawn; Taylor, Ewan; Vu, Phong
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4501 - 4505
反应条件
sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=20°C; 40 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/89915 A1, 2004 ;
Location in patent: Page 142-143 ;
反应条件
1: 91 percent / KOH / acetone / 5 h / Heating
2: 75 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
3: 79 percent / aq.NaOH / tetrabutylammonium hydrogen sulphate / 0.5 h / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, Pulla; Singh, P. P.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1236 - 1242
反应条件
1: 91 percent / KOH / acetone / 5 h / Heating
2: 75 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
3: 88 percent / aq.NaOH / tetrabutylammonium hydrogen sulphate / 0.5 h / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, Pulla; Singh, P. P.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1236 - 1242
反应条件
1: 90 percent / KOH / acetone / 5 h / Heating
2: 70 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
3: 82 percent / aq.NaOH / tetrabutylammonium hydrogen sulphate / 0.5 h / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, Pulla; Singh, P. P.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1236 - 1242
反应条件
1: 90 percent / KOH / acetone / 5 h / Heating
2: 70 percent / NH2OH*HCl, pyridine / ethanol / 2 h / Heating
3: 86 percent / aq.NaOH / tetrabutylammonium hydrogen sulphate / 0.5 h / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, Pulla; Singh, P. P.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1236 - 1242
反应条件
1: 90 percent / KOH / acetone / 5 h / Heating
2: 83 percent / pyridine / ethanol / 3 h / Ambient temperature
View Scheme
参考文献
Shridhar, D. R.; Sastry, C. V. Reddy; Bansal, O. P.; Rao, Pulla; Singh, P. P.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 12 p. 1236 - 1242
