5-金刚烷-1-基-[1,3,4]噻二唑-2-胺合成路线 （共 3 条）
反应条件
1: With sulfuric acid
T=20°C; 24 h;
2: With ammonium hydroxide in water
Cooling with ice;
参考文献
Kadi, Adnan A.; Al-Abdullah, Ebtehal S.; Shehata, Ihsan A.; Habib, Elsayed E.; Ibrahim, Tarek M.; El-Emam, Ali A.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5006 - 5011
反应条件
1: tricyclo[3.3.1.13,7 ]-decane-1-carboxylic acid With trichlorophosphate
T=20°C; 0.333333 h;
2: thiosemicarbazide in water
Reflux;
3: With potassium hydroxide in water
Cooling;
参考文献
Kadi, Adnan A.; Al-Abdullah, Ebtehal S.; Shehata, Ihsan A.; Habib, Elsayed E.; Ibrahim, Tarek M.; El-Emam, Ali A.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5006 - 5011
反应条件
1: 75 percent / HCl / H2O / 2 h / Heating
2: conc. H2SO4 / 24 h / Ambient temperature
View Scheme
参考文献
El-Emam, A. A.; Lehmann, J.
Monatshefte fuer Chemie, 1994 , vol. 125, # 5 p. 587 - 592
