6-氟-2,3-二甲氧基苯甲酸合成路线 （共 5 条）
反应条件
1: 4-fluoro-1,2-dimethoxybenzene With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-60°C; 1 h;
2: carbon dioxide in tetrahydrofuran; hexane
T=-60°C; 0.5 h;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 100 percent / HBr; AcOH / H2O / 1 h / Heating
2: 60 percent / SOCl2 / 18 h / 70 °C
3: 80 percent / Cs2CO3 / dimethylformamide / 1.5 h / 110 °C
4: 97 percent / KOH / methanol; H2O / 3 h / 20 °C
5: 93 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4.5 h / 100 °C
6: 94 percent / TFA / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
hydrogen bromide; acetic acid in water
1 h; Heating;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 100 percent / HBr; AcOH / H2O / 1 h / Heating
2: 60 percent / SOCl2 / 18 h / 70 °C
3: 80 percent / Cs2CO3 / dimethylformamide / 1.5 h / 110 °C
4: 97 percent / KOH / methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
1: 100 percent / HBr; AcOH / H2O / 1 h / Heating
2: 60 percent / SOCl2 / 18 h / 70 °C
3: 80 percent / Cs2CO3 / dimethylformamide / 1.5 h / 110 °C
4: 97 percent / KOH / methanol; H2O / 3 h / 20 °C
5: 93 percent / diphenoxyphosphoryl azide; Et3N / dioxane / 4.5 h / 100 °C
View Scheme
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
