2-羟基阿托伐他汀缩丙酮叔-丁酯合成路线 （共 2 条）
反应条件
1: HCl / tetrahydrofuran; H2O / 20 °C
2: sodium hydroxide / H2O; tetrahydrofuran / 20 °C
View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
Multi-step reaction with 3 steps 1: 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / Heating2: pivalic acid / tetrahydrofuran; toluene; heptane / Heating3: 35 percent / hydrogen; acetic acid / palladium on carbon / ethyl acetate
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
