N-苄氧羰基-D-丙氨酸合成路线 （共 30 条）
反应条件
ammonia; triethylamine; isobutyl chloroformate 1.) THF, -15 deg C, 10 min, 2.) -15 deg C to room temp., 1 h; Yield given. Multistep reaction;
参考文献
Noguchi, Takuya; Sekine, Masahiro; Yokoo, Yuki; Jung, Seunghee; Imai, Nobuyuki
Chemistry Letters, 2013 , vol. 42, # 6 p. 580 - 582
反应条件
(i) ClCO2Et, Et3N, THF, DMF, (ii) /BRN= 4235975/, H2O; Multistep reaction;
参考文献
Miroshnikov,A.I. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1970 , vol. 40, # 2 p. 429 - 443,395 - 407
反应条件
chloroform; triethylamine; toluene anschliessendes Behandeln mit L-Phenylalanin-aethylester und Behandeln des Reaktionsprodukts mit wss. NaOH;
参考文献
Fu et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 6054,6057
反应条件
ethylenediaminetetraacetic acid; phenyl-methyl-sulfonyl fluoride; water in aq. phosphate buffer T=30°C; Microbiological reactionEnzymatic reaction; Kinetics; Reagent/catalyst;
参考文献
Maurs, Michele; Acher, Francine; Azerad, Robert
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 22 - 26
反应条件
1: With thionyl chloride in tetrahydrofuran T=0°C; 0.166667 h; 2: With zinc(II) chloride in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
Long, Ya-Qiu; Huang, Shao-Xu; Zawahir, Zahrah; Xu, Zhong-Liang; Li, Huiyuan; Sanchez, Tino W.; Zhi, Ying; De Houwer, Stephanie; Christ, Frauke; Debyser, Zeger; Neamati, Nouri
Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5601 - 5612
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-15°C; 96 h;
参考文献
Akaji, Kenichi; Kuriyama, Naohiro; Kiso, Yoshiaki
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3350 - 3357
反应条件
boron trifluoride diethyl etherate T=-15°C;
参考文献
Kuriyama, Naohiro; Akaji, Kenichi; Kiso, Yoshiaki
Tetrahedron, 1997 , vol. 53, # 25 p. 8323 - 8334
反应条件
dicyclohexyl-carbodiimide in acetonitrile
T=-20°C;
参考文献
Kiviranta, Paeivi H.; Leppaenen, Jukka; Rinne, Valtteri M.; Suuronen, Tiina; Kyrylenko, Olga; Kyrylenko, Sergiy; Kuusisto, Erkki; Tervo, Anu J.; Jaervinen, Tomi; Salminen, Antero; Poso, Antti; Wallen, Erik A.A.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2448 - 2451
反应条件
triethylamine in N,N-dimethyl-formamide
T=0°C; 1 h;
参考文献
Vrudhula, Vivekananda M.; Kerr, David E.; Siemers, Nathan O.; Dubowchik, Gene M.; Senter, Peter D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 539 - 542
反应条件
1: N-[(phenylmethoxy)-carbonyl]-D-alanine With sodium hydride in tetrahydrofuran
T=0°C; 0.25 h;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C; Further stages.;
参考文献
Trouche, Nathalie; Wieckowski, Sebastien; Sun, Weimin; Chaloin, Olivier; Hoebeke, Johan; Fournel, Sylvie; Guichard, Gilles
Journal of the American Chemical Society, 2007 , vol. 129, # 44 p. 13480 - 13492
