4-(羟基甲基)-1-氮杂双环[2.2.2]辛烷合成路线 (共 6 条)
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
SmithKline Beecham p.l.c.
Patent: US6281226 B1, 2001 ;
反应条件
trifluoroacetic acid in tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile
参考文献
Air Products and Chemicals, Inc.
Patent: US5710191 A1, 1998 ;
参考文献
SmithKline Beecham p.l.c.
Patent: US6281226 B1, 2001 ;
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
1: potassium dichromate; acetic acid / Behandeln des Reaktionsprodukts mit Semicarbazid-hydrochlorid in Wasser
2: ethanolic sodium ethylate solution / 165 °C
View Scheme
参考文献
Grob; Renk
Helvetica Chimica Acta, 1954 , vol. 37, p. 1672,1676
反应条件
silver carbonate in toluene
9 h; Heating;
参考文献
Grob, Cyril A.; Schaub, Bruno; Schlageter, Markus G.
Helvetica Chimica Acta, 1980 , vol. 63, # 1 p. 57 - 62