(2S)-2-氨基-4-甲基戊酸甲酯合成路线 （共 67 条）
反应条件
T=25°C; 0.833333 h; enzyme alcalase from Bacillus licheniforms; pH 8.2;
参考文献
Weil; Kuhn
Helvetica Chimica Acta, 1944 , vol. 27, p. 1666
Helvetica Chimica Acta, 1946 , vol. 29, p. 790
反应条件
1H-imidazole; dicyclohexyl-carbodiimide in ethyl acetate
参考文献
Pellicciari, Roberto; Garzon-Aburbeh, Aaron; Natalini, Benedetto; Marinozzi, Maura; Clerici, Carlo; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 26 p. 4201 - 4207
反应条件
2-(N-morpholino)ethylamine; sodium hydrogencarbonate in 1,2-dichloro-ethane 0.5 h;
参考文献
Doelling, R.; Kaufmann, K.-D.
Journal fuer Praktische Chemie (Leipzig), 1984 , vol. 326, # 1 p. 171 - 174
反应条件
in N,N-dimethyl-formamide T=30°C; Rate constant;
参考文献
Wante, Dirk P. M.; Anteunis, Marc J. O.
Bulletin des Societes Chimiques Belges, 1984 , vol. 93, # 1 p. 73 - 82
反应条件
1: 77 percent / dicyclohexylcarbodi-imide, 1-hydroxybenzotriazole / dimethylformamide 2: 88 percent / sodium hydroxide / dioxane; H2O / 1 h / 0 °C 3: trifluoroacetic acid 4: hydrogen / 10percent palladium-charcoal / aq. acetic acid / 15 h View Scheme
参考文献
Holley; Sondheimer
Journal of the American Chemical Society, 1954 , vol. 76, p. 1326
反应条件
1.1: triethylamine / tetrahydrofuran / 20 - 50 °C 2.1: lithium aluminum hydride / tetrahydrofuran / 0.33 h 2.2: aq. potassium hydroxide / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bera, Saurav; Panda, Gautam
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 23 p. 3976 - 3985
反应条件
1: diethyl ether 2: methanol; aqueous NaOH 3: palladium; methanol; acetic acid / Hydrogenation View Scheme
参考文献
Carpenter; Gish
Journal of the American Chemical Society, 1952 , vol. 74, p. 3818,3819
反应条件
diethyl ether und Verseifung und Hydrogenolyse des Reaktionsprodukts;
参考文献
Nyman; Herbst
Journal of Organic Chemistry, 1950 , vol. 15, p. 108,115
反应条件
hydrogenchloride 0.5 h; Heating;
参考文献
Bull; Davies; Garner; O'Shea
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 24 p. 3281 - 3287
反应条件
1: 95 percent / N-ethylmorpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -5 - 20 °C 2: 82 percent / TsOH / methanol / 24 h / 20 °C 3: 86 percent / aq. HCl / 16 h / 20 °C View Scheme
参考文献
Kudyba, Iwona; Raczko, Jerzy; Jurczak, Janusz
Tetrahedron Letters, 2003 , vol. 44, # 48 p. 8685 - 8687
