(2S)-2-氨基-4-甲基戊酸甲酯合成路线 （共 67 条）
反应条件
hydrogenchloride in water
参考文献
Hanessian, Stephen; Wang, Xiaotian
Synlett, 2009 , # 17 p. 2803 - 2808
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Jones, Raymond C. F.; Bullous, James P.; Law, Carole C. M.; Elsegood, Mark R. J.
Chemical Communications, 2014 , vol. 50, # 13 p. 1588 - 1590
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Sudhakar, Gangarajula; Bayya, Shruthi; Reddy, Karla Janardhan; Sridhar, Balasubramanian; Sharma, Komal; Bathula, Surendar Reddy
European Journal of Organic Chemistry, 2014 , vol. 2014, # 6 p. 1253 - 1265
反应条件
1: 59 percent / DCC; HOBt / dimethylformamide 2: 99 percent / DMAP / acetonitrile 3: 49 percent / acetonitrile / 20 °C View Scheme
参考文献
Sameiro, M; Goncalves, T; Maia, Hernani L.S
Tetrahedron Letters, 2001 , vol. 42, # 44 p. 7775 - 7777
反应条件
1.1: 91 percent / DCC; HOBT; TsOH / Et3N / tetrahydrofuran / 0 °C 2.1: LiOH / tetrahydrofuran; H2O / 0 °C 2.2: H2 / Pd/C / methanol / 50 °C View Scheme
参考文献
Lee, Jin Hwan; Lee, Byong Won; Jang, Ki Chang; Jeong, Ill-Yun; Yang, Min Suk; Lee, Sang Gyeong; Park, Ki Hun
Synthesis, 2003 , # 6 p. 829 - 836
反应条件
boron trifluoride diethyl etherate; diborane in tetrahydrofuran T=20°C; 1 h;
参考文献
Grundon, Michael F.; McCleery, David G.; Wilson, John W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 231 - 235
反应条件
1: 95 percent / N-ethylmorpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -5 - 20 °C 2: 82 percent / TsOH / methanol / 24 h / 20 °C 3: 86 percent / aq. HCl / 16 h / 20 °C View Scheme
参考文献
Kudyba, Iwona; Raczko, Jerzy; Jurczak, Janusz
Tetrahedron Letters, 2003 , vol. 44, # 48 p. 8685 - 8687
反应条件
1: DCC 2: hydrogen bromide, glacial acetic acid 3: 63 percent / Et3N / CH2Cl2 / 0 °C 4: 92 percent / nitrosyl chloride, pyridine / CH2Cl2 View Scheme
参考文献
Montero; Leydet; Dewynter; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 3 p. 257 - 263
反应条件
3,3'-Dicyano-4,4',6,6'-tetramethyl-2,2'-dipyridinyl-disulfid; triphenylphosphine in dichloromethane T=-20 - -15°C; 12 h;
参考文献
Schmidt, Ulrich; Potzolli, Bernd
Liebigs Annalen der Chemie, 1987 , p. 935 - 942
反应条件
diethyl ether; chloroform
参考文献
Nyman; Herbst
Journal of Organic Chemistry, 1950 , vol. 15, p. 108,115
Full Text Show Details
Smith et al.
Journal of Biological Chemistry, 1952 , vol. 199, p. 801,808
