(2S)-2-氨基-4-甲基戊酸甲酯合成路线 （共 67 条）
反应条件
1: 80 percent / N,N'-dicyclohexylcarbodiimide, 1-hydroxybenztriazole
2: 1.) 4N HCl; 2.) N-methylmorpholine / 2.) 0.1M AcOH / 1.) dioxane, r.t., 30 min; 2.) 2-butanol, reflux, 3 h
View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
反应条件
in dichloromethane
72 h; Heating;
参考文献
Garcia, Jordi; Gonzalez, Javier; Segura, Ramon; Vilarrasa, Jaume
Tetrahedron, 1984 , vol. 40, # 16 p. 3121 - 3128
反应条件
diethyl ether; sodium carbonate; ethyl acetate
参考文献
Zeng, Le; Kaoudi, Talbi; Schiesser, Carl H.
Tetrahedron Letters, 2006 , vol. 47, # 45 p. 7911 - 7914
反应条件
1: 95 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF4 / CH2Cl2 / 20 °C
2: 98 percent / lithium hydroxide / methanol
View Scheme
参考文献
Styers, Thomas J.; Rodriguez, Rodrigo; Pan, Po-Shen; McAlpine, Shelli R.
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 515 - 517
反应条件
1: diethyl ether; aqueous KHCO3
2: methanol. NH3
View Scheme
参考文献
Smith; Slonim
Journal of Biological Chemistry, 1948 , vol. 176, p. 835,839
反应条件
triethylamine; dicyclohexyl-carbodiimide in dichloromethane
1) -5 deg C, 3 h 2) refrigerator, 48 h 3) room temperature, 4 h;
参考文献
Abou Ghalia, M. H.; Salem, Ezzeldin M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 135 - 138
反应条件
in N,N-dimethyl-formamide
T=-5 - 20°C;
参考文献
Spisani, Susanna; Turchetti, Marianna; Varani, Katia; Falzarano, Sofia; Cavicchioni, Giorgio
European Journal of Pharmacology, 2003 , vol. 469, # 1-3 p. 13 - 19
反应条件
triethylamine in benzene
T=20°C; 24 h; Title compound not separated from byproducts;
参考文献
Cavelier-Frontin, Florine; Jacquier, Robert; Paladino, Joseph; Verducci, Jean
Tetrahedron, 1991 , vol. 47, # 47 p. 9807 - 9822
反应条件
1: NaHCO3 / H2O
2: hydrazine hydrate / methanol / 18 h / 20 °C
View Scheme
参考文献
Curcio, Pasquale; Allix, Florent; Pickaert, Guillaume; Jamart-Gregoire, Brigitte
Chemistry - A European Journal, 2011 , vol. 17, # 48 p. 13603 - 13612
反应条件
sodium hydrogencarbonate in dichloromethane; water
T=0°C; 0.25 h;
参考文献
Sunder-Plassmann, Nils; Sarli, Vasiliki; Gartner, Michael; Utz, Mathias; Seiler, Jeanette; Huemmer, Stefan; Mayer, Thomas U.; Surrey, Thomas; Giannis, Athanassios
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6094 - 6111
