7-氯-3,4-二氢-2H-1-萘酮合成路线 （共 23 条）
反应条件
1: 1.) p-toluenesulfonic acid, 2.) DDQ / 1.) reflux, 14 h, 2.) from 80 to 90 deg C, 1.5 h
2: KOH / 1.2 h / Ambient temperature
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参考文献
Lowe III; Hageman; Drozda; McLean; Bryce; Crawford; Zorn; Morrone; Bordner
Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3789 - 3811
反应条件
1: 1.8 g / O2, K / 2-methyl-propan-2-ol / 4 h / Ambient temperature
2: 1.0 g / conc. HCl / 3 h / Heating
3: 1.) SnCl2, conc. HCl; 2.) 50percent KOH / 1.) EtOH, r.t., 1 h; 2.) reflux, 1 h
4: 2 mg / NaBH4, PdCl2 / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Inoue, Kenichiro; Ueda, Shinichi; Nayeshiro, Hidekazu; Moritome, Nobuharu; Inouye, Hiroyuki
Phytochemistry (Elsevier), 1984 , vol. 23, # 2 p. 313 - 318
反应条件
1: 1.8 g / O2, K / 2-methyl-propan-2-ol / 4 h / Ambient temperature
2: 1.0 g / conc. HCl / 3 h / Heating
3: 1.) SnCl2, conc. HCl; 2.) 50percent KOH / 1.) EtOH, r.t., 1 h; 2.) reflux, 1 h
4: 2 mg / NaBH4, PdCl2 / methanol / 1 h / Ambient temperature
5: 393 mg / BBr3 / CH2Cl2 / 2 h / Ambient temperature
6: 74 mg / K2CO3 / acetone / 3 h / Heating
7: 9.0 mg / ethanol / 8 h / Heating
View Scheme
参考文献
Inoue, Kenichiro; Ueda, Shinichi; Nayeshiro, Hidekazu; Moritome, Nobuharu; Inouye, Hiroyuki
Phytochemistry (Elsevier), 1984 , vol. 23, # 2 p. 313 - 318
