反应条件
1: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH2Cl2; 2.) CH2Cl2, 1 h, 0 deg C; 24 h at room temp.
2: 89 percent / 2 N NaOH / methanol / 2 h / 40 °C
3: 1.) N-methylmorpholin, 1-hydroxybenzotriazole; 2.) N,N'-dicyclohexylcarbodiimide / 1.) CH2Cl2; 2.) CH2Cl2, 30 min, 0 deg C; 12 h at room temp.
4: 97 percent / 1 N HCl, H2 / Pd/10percent on charcoal / methanol / 4 h
View Scheme
