三甲基1,3,5-苯三羟酸酯合成路线 （共 67 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.5 h; Ambient temperature;
参考文献
Merck Frosst Canada and Co.
Patent: US6121253 A1, 2000 ;
反应条件
lithium borohydride in tetrahydrofuran 0.5 h; Inert atmosphereReflux;
参考文献
Meng, Le; Cheng, Qigan; Kim, Chungsik; Gao, Wen-Yang; Wojtas, Lukasz; Zaworotko, Michael J.; Zhang, X. Peter; Ma, Shengqian; Chen, Yu-Sheng
Angewandte Chemie, International Edition, 2012 , vol. 51, # 40 p. 10082 - 10085,4
Angewandte Chemie, 2012 , vol. 124, # 40 p. 10229 - 10232,4
反应条件
1: 76 percent / 0.1 M aq. NaOH / methanol / 18 h 2: 88 percent / borane-methyl sulfide / tetrahydrofuran / 24 h / 27 °C 3: 93 percent / SOCl2 / 1 h / Heating View Scheme
参考文献
Dimick, Sarah M.; Powell, Steven C.; McMahon, Stephen A.; Moothoo, Davina N.; Naismith, James H.; Toone, Eric J.
Journal of the American Chemical Society, 1999 , vol. 121, # 44 p. 10286 - 10296
反应条件
hydroxylamine hydrochloride
参考文献
Hynes
Journal of medicinal chemistry, 1970 , vol. 13, # 6 p. 1235 - 1237
反应条件
1: 79 percent / LiAlH4 2: 98 percent / Dess-Martin reagent / CH2Cl2 / 15 h View Scheme
参考文献
Muth, Aaron; Madan, Meenu; Archer, Jennifer Julian; Ocampo, Nicolette; Rodriguez, Luis; Phanstiel, Otto
Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 348 - 363
反应条件
1: LiAlH4 / diethyl ether 2: SOCl2, Py / benzene View Scheme
参考文献
Cochrane,W.P. et al.
Journal of the Chemical Society [Section] C: Organic, 1968 , p. 630 - 632
参考文献
Cohen; Cypher
Industrial and Engineering Chemistry, 1958 , vol. 50, p. 1541
反应条件
1: LiAlH4 / tetrahydrofuran / 24 h / Heating 2: 19.12 g / aq. HBr / toluene / 24 h / Heating View Scheme
参考文献
Diez-Barra; Garcia-Martinez; Merino; Del Rey; Rodriguez-Lopez; Sanchez-Verdu; Tejeda
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5664 - 5670
反应条件
NaOH in neat (no solvent, solid phase) High Pressure; heated at 500°C for 3-12 h; cooled, washed (Et2O), dried (N2), SEM, XRD;
参考文献
Parast, Mohammad Sadegh Yazdan; Morsali, Ali
Inorganic Chemistry Communications, 2011 , vol. 14, # 5 p. 645 - 648
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 20 °C / |Inert atmosphere
2: phosphorus tribromide / diethyl ether / 16 h
3: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C
View Scheme
参考文献
Latorre, Alfonso; Lorca, Romina; Zamora, Felix; Somoza, Alvaro
Chemical Communications, 2013 , vol. 49, # 43 p. 4950 - 4952
