三甲基1,3,5-苯三羟酸酯合成路线 （共 67 条）
反应条件
1: 100 percent / LiAlH4 / tetrahydrofuran / 1.5 h / Ambient temperature
2: 92 percent / 30percent HBr/AcOH / 1 h / Heating
3: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 2 h
4: 85percent aq. KOH / 16 h / Heating
5: 3 h / 100 - 180 °C
View Scheme
参考文献
Yamagiwa, Yoshiro; Koreishi, Yoshiro; Kiyozumi, Satoshi; Kobayashi, Masanori; Kamikawa, Tadao; Tsukino, Mitsuji; Goi, Hironori; Yamamoto, Mikiko; Munakata, Megumu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 11 p. 3317 - 3323
反应条件
hydrogen; acetic acid; platinum(IV) oxide
T=25°C; P=1034.3 - 2585.7 Torr; 3.5 h;
参考文献
Nielsen, Arnold T.; Christian, Stephen L.; Moore, Donald W.; Gilardi, Richard D.; George, Clifford F.
Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1656 - 1662
反应条件
lithium aluminium tetrahydride; hydrogen iodide
1.) Et2O, reflux, 1 h; 2.) -30 deg C, 5 min; room temp., 0.5 h; Yield given. Multistep reaction;
参考文献
Bilger, Christine; Royer, Rene; Demerseman, Pierre
Synthesis, 1988 , # 11 p. 902 - 904
反应条件
1: 70 percent / NaOH
2: 49 percent / 1 M lithium triethylborohydride / tetrahydrofuran
3: 90 percent / PBr3
View Scheme
参考文献
Engel; Burris; Slate; Erickson
Tetrahedron, 1993 , vol. 49, # 39 p. 8761 - 8770
反应条件
1: 69 percent / NaOH / methanol / 12 h / Heating
2: 91 percent / tetrahydrofuran / 96 h / Heating
View Scheme
参考文献
Masuda, Mitsutoshi; Jonkheijm, Pascal; Sijbesma, Rint P.; Meijer
Journal of the American Chemical Society, 2003 , vol. 125, # 51 p. 15935 - 15940
反应条件
1: With water; sodium hydroxide in methanol
18 h;
2: With hydrogenchloride in water
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
sodium hydroxide in methanol
18 h; Heating; Title compound not separated from byproducts;
参考文献
Wilson, Andrew J.; Van Gestel, Jeroen; Sijbesma, Rint P.; Meijer
Chemical Communications, 2006 , # 42 p. 4404 - 4406
