N4-(3-氯-4-氟苯基)-7-(3-吗啉丙氧基)喹唑啉-4,6-二胺合成路线 （共 8 条）
反应条件
nickel monoaluminide in tetrahydrofuran
参考文献
Warner-Lambert Company
Patent: US6344455 B1, 2002 ;
US 6344455 B1
反应条件
1: in tetrahydrofuran; tert-butyl alcohol 24 h; Heating / reflux; 2: With potassium tert-butylate in tetrahydrofuran; tert-butyl alcohol T=15 - 20°C; 0.5 h;
参考文献
Warner-Lambert Company LLC
Patent: US6664390 B2, 2003 ;
Location in patent: Page column 8-9 ;
反应条件
hydrogenchloride; nickel monoaluminide in tetrahydrofuran; thionyl chloride; ethanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol
参考文献
Barth, Hubert; Steiner, Klaus; Schneider, Simon
Patent: US2003/50313 A1, 2003 ;
反应条件
1.1: Na / tetrahydrofuran / 2 h / 20 °C 1.2: 58 percent / tetrahydrofuran 2.1: 78 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating View Scheme
参考文献
Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397
反应条件
1.1: 72 percent / CH2Cl2; propan-2-ol / 0.5 h / 20 °C 2.1: Na / tetrahydrofuran / 2 h / 20 °C 2.2: 58 percent / tetrahydrofuran 3.1: 78 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating View Scheme
参考文献
Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397
反应条件
1.1: 72 percent / CH2Cl2; propan-2-ol / 0.5 h / 20 °C 2.1: Na / tetrahydrofuran / 2 h / 20 °C 2.2: 58 percent / tetrahydrofuran 3.1: 78 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating View Scheme
参考文献
Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397
反应条件
1.1: Na / tetrahydrofuran / 2 h / 20 °C 1.2: 58 percent / tetrahydrofuran 2.1: 78 percent / Fe; aq. HOAc / ethanol / 0.5 h / Heating View Scheme
参考文献
Smaill, Jeff B.; Rewcastle, Gordon W.; Loo, Joseph A.; Greis, Kenneth D.; Chan, O. Helen; Reyner, Eric L.; Lipka, Elke; Showalter, H. D. Hollis; Vincent, Patrick W.; Elliott, William L.; Denny, William A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1380 - 1397
反应条件
hydrogen; nickel in tetrahydrofuran
T=20°C; P=2625.26 Torr; 3 h; Heating / reflux;
参考文献
Warner-Lambert Company LLC
Patent: US6664390 B2, 2003 ;
Location in patent: Page column 8 ;
