1,4-二溴-2,5-二甲氧基苯合成路线 （共 25 条）
反应条件
boron tribromide in dichloromethane 24 h;
参考文献
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, , vol. 365, p. 481 - 489
反应条件
1: 79 percent / CuI; PPh3; Hunig 's base / Pd(PPh3)2Cl2 / tetrahydrofuran / 48 h / 55 °C
2: 98 percent / K2CO3 / methanol; CH2Cl2 / Heating
View Scheme
参考文献
Ichihara, Keisuke; Kawai, Hidetoshi; Togari, Yuka; Kikuta, Emi; Kitagawa, Hitomi; Tsuzuki, Seiji; Yoza, Kenji; Yamanaka, Masamichi; Kobayashi, Kenji
Chemistry - A European Journal, 2013 , vol. 19, # 11 p. 3685 - 3692
反应条件
1: 83 percent / bromine, iodine / CCl4 / Heating
2: 69 percent / n-BuLi / tetrahydrofuran; hexane / 3 h / -78 °C
3: 99 percent / 0.5 h / 180 °C / 20 Torr
View Scheme
参考文献
Hart, Harold; Lai, Chung-yin; Nwokogu, Godson Chukuemaka; Shamouilian, Shamouil
Tetrahedron, 1987 , vol. 43, # 22 p. 5203 - 5224
反应条件
1.1: n-butyllithium; DMF / diethyl ether; hexane / 0.42 h / 0 °C
1.2: 81 percent / hexane / 0.17 h / Heating
2.1: 100 percent / sodium borohydride / methanol / 0 - 20 °C
View Scheme
参考文献
Layton, Mark E.; Morales, Carl A.; Shair, Matthew D.
Journal of the American Chemical Society, 2002 , vol. 124, # 5 p. 773 - 775
反应条件
1: 1.) t-BuLi, ZnCl2, 2.) Pd(PPh3)4 / 1.) THF, -78 deg C, 1 h; room temperature, 2 h; room temperature, 1 h, 2.) THF, 55 deg C, 12 h
2: 92 percent / CAN / H2O; acetonitrile / 0.08 h
View Scheme
参考文献
Palmgren, Andreas; Thorarensen, Atli; Baeckvall, Jan-E.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3764 - 3768
