(R)-2-乙酰氨基-2-(2-氟苯基)丙酸合成路线 （共 4 条）
反应条件
L-prolinol resolution;
参考文献
Brauer, David J.; Schenk, Stefan; Rossenbach, Stefan; Tepper, Michael; Stelzer, Othmar; Haeusler, Thomas; Sheldrick, William S.
Journal of Organometallic Chemistry, 2000 , vol. 598, # 1 p. 116 - 126
反应条件
1: 77 percent / (NH4)2CO3 / H2O; ethanol / 2 h / 40 °C 2: 72 percent / 85 percent KOH / H2O / 48 h / Heating 3: 88 percent / NaHCO3 / H2O; dioxane / 4 h / 50 °C 4: 96 percent / (S)-(+)-2-hydroxymethylpyrrolidine View Scheme
参考文献
Brauer, David J.; Schenk, Stefan; Rossenbach, Stefan; Tepper, Michael; Stelzer, Othmar; Haeusler, Thomas; Sheldrick, William S.
Journal of Organometallic Chemistry, 2000 , vol. 598, # 1 p. 116 - 126
反应条件
1: 88 percent / NaHCO3 / H2O; dioxane / 4 h / 50 °C 2: 96 percent / (S)-(+)-2-hydroxymethylpyrrolidine View Scheme
参考文献
Brauer, David J.; Schenk, Stefan; Rossenbach, Stefan; Tepper, Michael; Stelzer, Othmar; Haeusler, Thomas; Sheldrick, William S.
Journal of Organometallic Chemistry, 2000 , vol. 598, # 1 p. 116 - 126
反应条件
1: 72 percent / 85 percent KOH / H2O / 48 h / Heating 2: 88 percent / NaHCO3 / H2O; dioxane / 4 h / 50 °C 3: 96 percent / (S)-(+)-2-hydroxymethylpyrrolidine View Scheme
参考文献
Brauer, David J.; Schenk, Stefan; Rossenbach, Stefan; Tepper, Michael; Stelzer, Othmar; Haeusler, Thomas; Sheldrick, William S.
Journal of Organometallic Chemistry, 2000 , vol. 598, # 1 p. 116 - 126
