4-氧代-4-吡啶-2-基丁酸乙酯合成路线 （共 10 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Negishi coupling reaction; 4 h; Inert atmosphere;
参考文献
Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184
反应条件
sulfuric acid T=85°C;
参考文献
Atobe, Masakazu; Maekawara, Naomi; Ishiguro, Noriko; Sogame, Shinya; Suenaga, Yoshihito; Kawanishi, Masashi; Suzuki, Hiroko; Jinno, Norimasa; Tanaka, Eiichi; Miyoshi, Shiro
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2106 - 2110
反应条件
toluene-4-sulfonic acid in benzene 16 h; Heating;
参考文献
Imoto, Hiroshi; Sugiyama, Yasuo; Kimura, Hiroyuki; Momose, Yu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 2 p. 138 - 151
反应条件
1.1: NaH / tetrahydrofuran / 0.17 h / 0 °C 1.2: tetrahydrofuran / 8 h / 0 °C 2.1: p-toluenesufonic acid monohydrate / toluene / 20 h / 80 °C View Scheme
参考文献
Hoffman, Robert V.; Kim, Hwa-Ok
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5107 - 5113
反应条件
1.1: carbonyldiimidazole / tetrahydrofuran / 2.5 h / 0 - 20 °C 1.2: tetrahydrofuran / 0.25 h / -78 °C 2.1: NaH / tetrahydrofuran / 0.17 h / 0 °C 2.2: tetrahydrofuran / 8 h / 0 °C 3.1: p-toluenesufonic acid monohydrate / toluene / 20 h / 80 °C View Scheme
参考文献
Imoto, Hiroshi; Sugiyama, Yasuo; Kimura, Hiroyuki; Momose, Yu
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 2 p. 138 - 151
反应条件
Saccharomyces cerevisiae; water T=20°C; 384 h;
参考文献
Forzato, Cristina; Furlan, Giada; Nitti, Patrizia; Pitacco, Giuliana; Valentin, Ennio; Zangrando, Ennio; Buzzini, Pietro; Goretti, Marta; Turchetti, Benedetta
Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2026 - 2036
反应条件
1: sodium; benzene 2: concentrated aqueous HCl; ethanolic HCl View Scheme
参考文献
Winterfeld; Holschneider
Archiv der Pharmazie (Weinheim, Germany), 1935 , vol. 273, p. 305,311
反应条件
sodium ethanolate; benzene anschliessend Erhitzen mit wss. HCl und mit aethanol. HCl;
参考文献
Clemo et al.
Journal of the Chemical Society, 1932 , p. 2959,2965
反应条件
1: aqueous HCl; amalgamated zinc / Behandeln des Reaktionsprodukts mit aethanol. HCl
2: ethanol; sodium
View Scheme
参考文献
Clemo et al.
Journal of the Chemical Society, 1932 , p. 2959,2965
反应条件
water; sodium hydroxide in methanol
T=20°C;
参考文献
Amat, Mercedes; Arroniz, Carlos; Molins, Elies; Escolano, Carmen; Bosch, Joan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2175 - 2184
