1-溴-3,4,5-三甲氧基苯合成路线 （共 68 条）
参考文献
Larsson,S.; Miksche,G.E.
Acta Chemica Scandinavica (1947-1973), 1972 , vol. 26, p. 2031 - 2038
反应条件
pyridine; NiI2; 4-chloro-2-(4,5-dihydro-1H-imidazol-2-yl)pyridine; tetrabutylammomium bromide; magnesium chloride; zinc in N,N-dimethyl acetamide T=60°C; 12 h; Schlenk techniqueInert atmosphere; Reagent/catalystTemperature; regioselective reaction;
参考文献
Cui, Xiaozhan; Wang, Shulin; Zhang, Yuwei; Deng, Wei; Qian, Qun; Gong, Hegui
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 19 p. 3094 - 3097
反应条件
tetrakis(triphenylphosphine) palladium(0); cesium fluoride in tetrahydrofuran T=85°C; Suzuki-Miyaura coupling; 24 h; Inert atmosphere;
参考文献
Gerbino, Dario C.; Mandolesi, Sandra D.; Schmalz, Hans-Guenther; Podesta, Julio C.
European Journal of Organic Chemistry, 2009 , # 23 p. 3964 - 3972
反应条件
tert.-butyl lithium 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 to -65 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Pettit, George R.; Toki, Brian; Herald, Delbert L.; Verdier-Pinard, Pascal; Boyd, Michael R.; Hamel, Ernest; Pettit, Robin K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1688 - 1695
反应条件
2,6-di-tert-butyl-4-methyl-phenol; tetrakis(triphenylphosphine) palladium(0) in toluene 16 h; Heating;
参考文献
Wang, Zhaohui; Doetz, Florian; Enkelmann, Volker; Muellen, Klaus
Angewandte Chemie - International Edition, 2005 , vol. 44, # 8 p. 1247 - 1250
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With methanol in tetrahydrofuran Reactivity;
参考文献
Journal of Organic Chemistry, , vol. 74, # 7 p. 2760 - 2764
反应条件
L-proline in N,N-dimethyl-formamide T=120°C; Rosenmund-von Braun reaction; 45 h;
参考文献
Wang, Deping; Kuang, Liping; Li, Zhengwei; Ding, Ke
Synlett, 2008 , # 1 p. 69 - 72
反应条件
tetrabutylammomium bromide; copper (II) acetate monohydrate; potassium iodide in water T=180°C; 22 h;
参考文献
Ren, Yunlai; Zhao, Shuang; Tian, Xinzhe; Liu, Zhifei; Wang, Jianji; Yin, Weiping
Letters in Organic Chemistry, 2009 , vol. 6, # 7 p. 564 - 567
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 25 min, 2.) -78 deg C, 10 min; Yield given. Multistep reaction;
参考文献
Hoye, Thomas R.; Kaese, Paul A.
Synthetic Communications, 1982 , vol. 12, # 1 p. 49 - 52
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II); 1,3-bis-(diphenylphosphino)propane; triethylamine in toluene T=100°C; 18 h; Inert atmosphere;
参考文献
Rosen, Brad M.; Huang, Chenghong; Percec, Virgil
Organic Letters, 2008 , vol. 10, # 12 p. 2597 - 2600
