2-氨基-4,5-二甲氧基苯甲酸甲酯合成路线 （共 34 条）
反应条件
ammonium formate; palladium on activated charcoal in methanol 0.666667 h; Ambient temperature;
参考文献
Variyar, Prasad S.; Bandyopadhyay, Chiranjib
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 10 p. 911 - 913
反应条件
hydrogen; nitric acid; nickel 1.) AcOH, 60 deg C, 1 h, 2.) 50 deg C, 75 ats, 48 h; Yield given. Multistep reaction;
参考文献
Variyar, Prasad S.; Bandyopadhyay, Chiranjib
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 10 p. 911 - 913
反应条件
thionyl chloride 14 h; Heating;
参考文献
Hinsberger, Stefan; Huesecken, Kristina; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8332 - 8338
反应条件
1: 70 percent / HCl gas / 8 h / Heating 2: 56 percent / POCl3 / 8 h / Heating View Scheme
参考文献
Gokaraju, Ganga Raju; Kasina, Sudhakar; Somepalli, Venkateswarlu; Gokaraju, Rama Raju; Gokaraju, Venkata Kanaka Ranga Raju; Bhupathiraju, Kiran; Golakoti, Trimurtulu; Sengupta, Krishanu; Alluri, Venkata Krishna Raju
Patent: US2013/266563 A1, 2013 ;
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: NaOH / H2O; methanol 2: HOAc / H2O 3: 85 percent / POCl3, PhNMe2 4: NaOH / tetrahydrofuran; H2O View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1.1: Heating 2.1: tetrahydrofuran / -78 °C 2.2: AcOH / 20 °C View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1: 79 percent / conc. HCl / dioxane / 7.5 h / 80 °C 2: 38 percent / POCl3 / 8 h / Heating View Scheme
参考文献
Bridges; Zhou; Cody; Rewcastle; McMichael; Showalter; Fry; Kraker; Denny
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 267 - 276
反应条件
hydrogenchloride T=20°C; 3.5 h; Reflux;
参考文献
Gokaraju, Ganga Raju; Kasina, Sudhakar; Somepalli, Venkateswarlu; Gokaraju, Rama Raju; Gokaraju, Venkata Kanaka Ranga Raju; Bhupathiraju, Kiran; Golakoti, Trimurtulu; Sengupta, Krishanu; Alluri, Venkata Krishna Raju
Patent: US2013/266563 A1, 2013 ;
Location in patent: Paragraph 0326 ;
反应条件
potassium carbonate Acetylation;
参考文献
Rehwald, Matthias; Bellmann, Peter; Jeschke, Torsten; Gewald, Karl
Advanced Synthesis and Catalysis, 2000 , vol. 342, # 4 p. 371 - 378
