2-氨基-4,5-二甲氧基苯甲酸甲酯合成路线 （共 34 条）
反应条件
1: acid 2: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating 3: ammonia / H2O; tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Kumaraswamy; Jena, Nivedita; Sastry; Kumar, B. Ashok
Organic Preparations and Procedures International, 2004 , vol. 36, # 4 p. 341 - 345
反应条件
triethylamine in acetonitrile T=175°C; 0.5 h; Microwave irradiationSealed vial;
参考文献
Redondo, Miriam; Zarruk, Juan G.; Ceballos, Placido; Perez, Daniel I.; Perez, Concepcion; Perez-Castillo, Ana; Moro, Maria A.; Brea, Jose; Val, Cristina; Cadavid, Maria I.; Loza, Maria I.; Campillo, Nuria E.; Martinez, Ana; Gil, Carmen
European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 175 - 185
反应条件
1: methanol; N,N-dimethyl-formamide / |Inert atmosphere 2: dl-methionine; methanesulfonic acid / |Inert atmosphere 3: pyridine / |Inert atmosphere 4: thionyl chloride / N,N-dimethyl-formamide / |Inert atmosphere 5: isopropyl alcohol / |Inert atmosphere View Scheme
参考文献
Li, Zhengqiu; Hao, Piliang; Li, Lin; Tan, Chelsea Y. J.; Cheng, Xiamin; Chen, Grace Y. J.; Sze, Siu Kwan; Shen, Han-Ming; Yao, Shao Q.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., 2013 , vol. 125, # 33 p. 8713 - 8718,6
反应条件
1: 1.) NaBH4 / 1.) 20 deg C, 2.) 80 deg C, 9 h 2: 40 percent / conc. NH3 / methanol / 360 h / Ambient temperature 3: 90 percent / pyridine / Ambient temperature 4: 25 percent / BBr3 / CH2Cl2 / -75 - 20 °C 5: 20 percent / 0.2 N aq. NaOH / 64 h / Ambient temperature View Scheme
参考文献
Variyar, Prasad S.; Bandyopadhyay, Chiranjib
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 10 p. 911 - 913
反应条件
in formamide T=190 - 200°C; 2 h;
参考文献
Cai, Xiong; Qian, Changgeng; Zhai, Haixiao; Bao, Rudi
Patent: US2009/111772 A1, 2009 ;
Location in patent: Page/Page column 54; 64 ;
US 20090111772 A1
反应条件
ammonia; acetic acid T=150°C; 2 h; Product distribution / selectivity;
参考文献
Mitsubishi Gas Chemical Company, Inc.
Patent: EP1997812 A1, 2008 ;
Location in patent: Page/Page column 6 ;
反应条件
sodium methylate; formamide in methanol; N,N-dimethyl-formamide 10 h; Heating;
参考文献
Furuta, Takayuki; Sakai, Teruyuki; Senga, Terufumi; Osawa, Tatsushi; Kubo, Kazuo; Shimizu, Toshiyuki; Suzuki, Rika; Yoshino, Tetsuya; Endo, Megumi; Miwa, Atsushi
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 97 percent / formamide; sodium methoxide / dimethylformamide; methanol / 10 h / Heating 2: 86 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Kubo, Kazuo; Shimizu, Toshiyuki; Ohyama, Shin-Ichi; Murooka, Hideko; Iwai, Akemi; Nakamura, Kazuhide; Hasegawa, Kazumasa; Kobayashi, Yoshiko; Takahashi, Noriko; Takahashi, Kazumi; Kato, Shinichiro; Izawa, Toshio; Isoe, Toshiyuki
Journal of Medicinal Chemistry, 2005 , vol. 48, # 5 p. 1359 - 1366
反应条件
1: 180 °C 2: 1.) methionine, MeSO3H / 1.) 100 deg C, 3 h, 2.) Py View Scheme
参考文献
Li, Zhengqiu; Hao, Piliang; Li, Lin; Tan, Chelsea Y. J.; Cheng, Xiamin; Chen, Grace Y. J.; Sze, Siu Kwan; Shen, Han-Ming; Yao, Shao Q.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., 2013 , vol. 125, # 33 p. 8713 - 8718,6
反应条件
1: methanol; N,N-dimethyl-formamide / |Inert atmosphere 2: dl-methionine; methanesulfonic acid / |Inert atmosphere 3: pyridine / |Inert atmosphere 4: thionyl chloride / N,N-dimethyl-formamide / |Inert atmosphere 5: isopropyl alcohol / |Inert atmosphere 6: ammonium hydroxide / 3 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Li, Zhengqiu; Hao, Piliang; Li, Lin; Tan, Chelsea Y. J.; Cheng, Xiamin; Chen, Grace Y. J.; Sze, Siu Kwan; Shen, Han-Ming; Yao, Shao Q.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8551 - 8556
Angew. Chem., 2013 , vol. 125, # 33 p. 8713 - 8718,6
