2-甲氧基-1-(4’-三氟甲基)苯乙酮合成路线 （共 10 条）
反应条件
water; hydrogenchloride in methanol T=20°C; 36 h;
参考文献
CENTRAL GLASS COMPANY, LIMITED
Patent: WO2004/14887 A1, 2004 ;
Location in patent: Page 30-33 ;
反应条件
1: 1-fluoro-4-(trifluoromethyl)benzene With n-butyllithium in tetrahydrofuran; hexane 0.0833333 h; 2: N-methoxy-2-methoxy-N-methylacetamide in tetrahydrofuran T=20°C; 4 h;
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
sulfuric acid in methanol; water 5 h; Heating / reflux;
参考文献
Schering Corporation
Patent: US2003/208074 A1, 2003 ;
Location in patent: Page/Page column 8; 16 ;
反应条件
1: (methoxymethyl)-triphenylphosphonium chloride With phenyllithium in tetrahydrofuran T=0°C; Dehydrochlorination; 0.166667 h; 2: p-(trifluoromethyl)-benzonitrile in tetrahydrofuran T=20°C; Alkylation; 2 h; 3: With water in tetrahydrofuran Hydrolysis;
参考文献
Camuzat-Dedenis; Provot; Moskowitz; Mayrargue
Synthesis, 1999 , # 9 p. 1558 - 1560
反应条件
in methanol T=20°C; 24 h;
参考文献
CENTRAL GLASS COMPANY, LIMITED
Patent: WO2004/14887 A1, 2004 ;
Location in patent: Page 27-28 ;
反应条件
in methanol T=20°C; 24 h;
参考文献
CENTRAL GLASS COMPANY, LIMITED
Patent: WO2004/14887 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
boron trifluoride diethyl etherate; silver(l) oxide T=20°C; 22 h;
参考文献
Feng, Dong-Zhi; Song, Yan-Li; Jiang, Xiao-Hua; Chen, Li; Long, Ya-Qiu
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2690 - 2697
反应条件
1: borane dimethylsulfide; (S)-2-methyl-CBS-oxaborolidine / 1 h 2: triethylamine / CH2Cl2 / 0.5 h / cooling 3: 14.8 g / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
1.1: borane dimethylsulfide; (S)-2-methyl-CBS-oxaborolidine / 1 h 2.1: triethylamine / CH2Cl2 / 0.5 h / cooling 3.1: 14.8 g / K2CO3 / acetonitrile / 72 h / Heating 4.1: 7.9 g / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C 5.1: Ti(OiPr)4 / CH2Cl2 / 20 h / 20 °C 5.2: 13.4 g / CH2Cl2; toluene / 20 h 6.1: 76 percent / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
1.1: borane dimethylsulfide; (S)-2-methyl-CBS-oxaborolidine / 1 h
2.1: triethylamine / CH2Cl2 / 0.5 h / cooling
3.1: 14.8 g / K2CO3 / acetonitrile / 72 h / Heating
4.1: 7.9 g / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C
5.1: Ti(OiPr)4 / CH2Cl2 / 20 h / 20 °C
5.2: 13.4 g / CH2Cl2; toluene / 20 h
6.1: 76 percent / tetrahydrofuran / 48 h / 20 °C
7.1: 100 percent / trifluoroacetic acid / CH2Cl2 / 6 h / 20 °C
View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
