3-氯-N-(1,3-噻唑-2-基)丙酰胺合成路线 (共 2 条)
反应条件
1: 2-amino-thiazole With sodium hydride in tetrahydrofuran; mineral oil 6 h; Inert atmosphere; 2: 3-chloropropanoyl chloride in tetrahydrofuran; mineral oil T=20°C; Inert atmosphere;
参考文献
Bodill, Taryn; Conibear, Anne C.; Mutorwa, Marius K.M.; Goble, Jessica L.; Blatch, Gregory L.; Lobb, Kevin A.; Klein, Rosalyn; Kaye, Perry T.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4332 - 4341
反应条件
potassium iodide in ethanol 48 h; Heating;
参考文献
Westland,R.D. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, # 10 p. 916 - 920