5-溴-2-苯基-4(3H)-嘧啶酮合成路线 (共 2 条)
反应条件
N-bromosuccinmide; acetic acid T=60°C; 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/3099 A2, 2005 ;
Location in patent: Page 131 ;
WO 2005/003099 A2
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(I) bromide dimethylsulfide complex in tetrahydrofuran Liebeskind-Srogl cross-coupling; 24 h; Inert atmosphereReflux;
参考文献
Sun, Qi; Suzenet, Franck; Guillaumet, Gerald
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3473 - 3476