dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II) in water; tert-butyl alcohol T=95°C; Suzuki-Miyaura cross-coupling; 22 h; Inert atmosphere;

palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water; toluene T=85°C; Suzuki-Miyaura cross-coupling reaction; 22 h; Inert atmosphere;

C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;

1.1: potassium hexamethylsilazane / tetrahydrofuran / 2.25 h / -78 - 20 °C 1.2: 1 h / 0 °C 1.3: 0 - 20 °C 2.1: KHF2 / methanol; water / 0 - 20 °C 3.1: palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / water; toluene / 22 h / 85 °C / Inert atmosphere View Scheme

1.1: sodium hydride / mineral oil; ethylene glycol dimethyl ether / 0.17 h / 0 - 20 °C 1.2: 16 h / 0 - 20 °C 2.1: C45H59ClNPPd; potassium carbonate / tert-butyl alcohol; water / 3 h / 85 °C / |Inert atmosphere View Scheme