1,1-二甲基-4-氧代-哌啶鎓碘化物合成路线 （共 14 条）
反应条件
sodium hydroxide in water T=65°C; 1.5 h;
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Reamer, Robert A.; Zhao, Dalian; Zhou, George; Gong, Xiaoyi
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 939 - 941
反应条件
1: 90 percent / potassium carbonate / ethanol; H2O / 0.5 h / Heating
2: 1) m-(chloroperoxy)benzoic acid, 2) triethylamine, acetic anhydride / 1) diethyl ether/dichloromethane, 0 to 20 deg C, 2 h, 2) CH2Cl2, 0 deg C, 30 min
3: 90 percent / 10percent aq. sulfuric acid / ethanol / 4 h / 20 °C
View Scheme
参考文献
Kuehne, Martin E.; Muth, Randy S.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2701 - 2712
反应条件
1: 87 percent / sodium acrylate / H2O
2: 99 percent / Raney Ni; HCl / ethanol; propan-2-ol
3: thionyl chloride
View Scheme
参考文献
Chung, John Y. L.; Cvetovich, Raymond J.; McLaughlin, Mark; Amato, Joseph; Tsay, Fuh-Rong; Jensen, Mark; Weissman, Steve; Zewge, Daniel
Journal of Organic Chemistry, 2006 , vol. 71, # 22 p. 8602 - 8609
反应条件
1: 90 percent / potassium carbonate / ethanol; H2O / 0.5 h / Heating
2: 1) m-(chloroperoxy)benzoic acid, 2) triethylamine, acetic anhydride / 1) diethyl ether/dichloromethane, 0 to 20 deg C, 2 h, 2) CH2Cl2, 0 deg C, 30 min
3: 90 percent / 10percent aq. sulfuric acid / ethanol / 4 h / 20 °C
View Scheme
参考文献
Kuehne, Martin E.; Muth, Randy S.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2701 - 2712
