2-氨基-4-甲基苯甲腈合成路线 （共 24 条）
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) KI 2: aq. NaOH View Scheme
参考文献
Gore,P.H. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2940 - 2948
反应条件
in hydrogenchloride; dichloromethane; water
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US5891909 A1, 1999 ;
US 5891909 A
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
反应条件
Diazotization.durch Austausch von NH2 gegen CN;
参考文献
Glock
Chemische Berichte, 1888 , vol. 21, p. 2652
Full Text Show Details
Niementowski
Monatshefte fuer Chemie, 1891 , vol. 12, p. 625
参考文献
Niementowski
Chemische Berichte, 1888 , vol. 21, p. 1539
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 15
反应条件
1: potassium hydroxide; water
2: Behandeln mit Wasser
View Scheme
参考文献
Niementowski
Journal fuer Praktische Chemie (Leipzig), 1889 , vol. <2> 40, p. 12
反应条件
1: potassium hydroxide; water
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
参考文献
Bogert; Hoffman
Journal of the American Chemical Society, 1905 , vol. 27, p. 1301
反应条件
in acetic acid
Heating;
参考文献
Hamdan, Ali; Wasley, Jan W. F.
Synthetic Communications, 1983 , vol. 13, # 9 p. 741 - 744
反应条件
1: potassium hydroxide / ethanol / 8 h / |Reflux
2: 6 h / 100 °C
3: acetic acid; bromine / methanol / 5 h / 20 °C
4: sulfuric acid; potassium nitrate / 0.33 h / 80 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
