1,4-二噁螺[4.5]癸烷-8-羧酸甲酯合成路线 （共 13 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; 3 h;
参考文献
Kitbunnadaj, Ruengwit; Hoffmann, Marcel; Fratantoni, Silvina A.; Bongers, Gerold; Bakker, Remko A.; Wieland, Kerstin; El Jilali, Ahmed; De Esch, Iwan J. P.; Menge, Wiro M. P. B.; Timmerman, Henk; Leurs, Rob
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6309 - 6323
反应条件
1: 90 percent / LAH / diethyl ether / 5 h / Ambient temperature 2: Et3N / CH2Cl2 / 2 h / 0 °C 3: dimethylsulfoxide / 3 h / Heating View Scheme
参考文献
King, Frank D.; Hadley, Michael S.; Joiner, Karen T.; Martin, Roger T.; Sanger, Gareth J.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 683 - 689
反应条件
1: 95 percent / LiAlH4 / diethyl ether / 3 h / 20 °C
2: 97 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 2 h / -60 - 20 °C
View Scheme
参考文献
HANMI PHARM. CO., LTD.; JUNG, Seung Hyun; KIM, Ji Sook; HONG, Dong Jin; JUNG, Young Hee; JANG, Wook
Patent: WO2013/157792 A1, 2013 ;
