2,5-二羟基苯基乙酸GAMMA内酯合成路线 （共 19 条）
参考文献
Bloomer, James L.; Damodaran, Kalyani M.
Synthesis, 1980 , # 2 p. 111
反应条件
potassium hydroxide in ethanol 11 h; Ambient temperature;
参考文献
Barbier, Michel
Liebigs Annalen der Chemie, 1987 , p. 545 - 546
反应条件
potassium hydroxide in ethanol T=20°C; pH=8; 15 h; Title compound not separated from byproducts;
参考文献
Venkateswarlu, Somepalli; Panchagnula, Gopala K.; Guraiah, Mothukuri Bala; Subbaraju, Gottumukkala V.
Tetrahedron, 2006 , vol. 62, # 42 p. 9855 - 9860
反应条件
1: With potassium hydroxide in ethanol T=20°C; 12 h; 2: With hydrogenchloride; water in ethanol T=20°C; 4 h;
参考文献
Lee, Chong-Yew; Chew, Eng-Hui; Go, Mei-Lin
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2957 - 2971
参考文献
Synthesis, , # 2 p. 111
反应条件
1: 66 percent / NH3 / tetrahydrofuran 2: BH3 / tetrahydrofuran View Scheme
参考文献
Ozaki, Yutaka; Quan, Zhe-Shan; Watabe, Kyouko; Kim, Sang-Won
Heterocycles, 1999 , vol. 51, # 4 p. 727 - 731
反应条件
1: 66 percent / NH3 / tetrahydrofuran 2: BH3 / tetrahydrofuran 3: aq. NH3, air / methanol View Scheme
参考文献
Ozaki, Yutaka; Quan, Zhe-Shan; Watabe, Kyouko; Kim, Sang-Won
Heterocycles, 1999 , vol. 51, # 4 p. 727 - 731
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 3 h / -78 °C
2: 84 percent / triethylamine, 4-dimethylaminopyridine / dimethylformamide / 25 h / from 0 deg C to room temperature
3: 87 percent / 50percent aq. HF / acetonitrile; CH2Cl2 / 1.8 h / Ambient temperature
4: 97 percent / oxalyl chloride, dimethylsulfoxide / CH2Cl2 / 0.75 h / -60 - -10 °C
5: p-toluenesulfonic acid / benzene / 47 h / Heating
6: 1M tetrabutylammonium fluoride, acetic acid / tetrahydrofuran / 0.25 h / 0 °C
View Scheme
参考文献
Hangauer, David G.
Tetrahedron Letters, 1986 , vol. 27, # 48 p. 5799 - 5802
参考文献
Fry
Journal of Organic Chemistry, 1952 , vol. 17, p. 1484,1488
