4-(2-氟-4-硝基苯基)吗啉合成路线 （共 14 条）
反应条件
in tetrahydrofuran T=0 - 20°C; 1.25 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/58317 A1, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/058317 A1
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MCCARTHY, James, R.
Patent: WO2011/137222 A1, 2011 ;
Location in patent: Example 2 ;
反应条件
in dimethyl sulfoxide
参考文献
ABBOTT LABAORATORIES
Patent: US2010/317568 A1, 2010 ;
反应条件
1: 91 percent / HNO3; H2SO4 / 6 h / 60 - 70 °C 2: 55 percent / dimethylsulfoxide / 2 h / Heating View Scheme
参考文献
Zhumabaeva; Kotovskaya; Perova; Charushin; Chupakhin
Russian Chemical Bulletin, 2006 , vol. 55, # 7 p. 1243 - 1247
反应条件
1: fluorine; sulfuric acid 2: Neat (no solvent) View Scheme
参考文献
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MCCARTHY, James, R.
Patent: WO2011/137222 A1, 2011 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/58317 A1, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/058317 A1
反应条件
1.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 2.1: NaHCO3 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: hexane; tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Brickner, Steven J.; Hutchinson, Douglas K.; Barbachyn, Michael R.; Manninen, Peter R.; Ulanowicz, Debra A.; et al.
J. Med. Chem., 1996 , vol. 39, # 3 p. 673 - 679
反应条件
1.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 2.1: NaHCO3 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: hexane; tetrahydrofuran / -78 - 20 °C 4.1: Et3N 5.1: NH3 / methanol View Scheme
参考文献
Brickner, Steven J.; Hutchinson, Douglas K.; Barbachyn, Michael R.; Manninen, Peter R.; Ulanowicz, Debra A.; et al.
J. Med. Chem., 1996 , vol. 39, # 3 p. 673 - 679
反应条件
1.1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 2.1: NaHCO3 3.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 3.2: hexane; tetrahydrofuran / -78 - 20 °C 4.1: Et3N 5.1: NH3 / methanol 6.1: 2 h / 40 °C View Scheme
参考文献
ALEMBIC LIMITED; RAMAN, Jayaraman, Venkat; RATHOD, Dhiraj; VOHRA, Irfan; CHAVAN, Mangesh; AHIRRAO, Manoj; PONNAIAH, Ravi
Patent: WO2011/77310 A1, 2011 ;
反应条件
1: ammonium formate / 10 percent Pd/C / methanol; tetrahydrofuran 2: NaHCO3 View Scheme
参考文献
ALEMBIC LIMITED; RAMAN, Jayaraman, Venkat; RATHOD, Dhiraj; VOHRA, Irfan; CHAVAN, Mangesh; AHIRRAO, Manoj; PONNAIAH, Ravi
Patent: WO2011/77310 A1, 2011 ;
