4-(2-氟-4-硝基苯基)吗啉合成路线 （共 14 条）
反应条件
1: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr 2: Et3N / tetrahydrofuran / 2 h / 20 °C 3: sodium azide / dimethylformamide / 6 h / 65 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 4 p. 353 - 360
反应条件
1: hydrogen / Raney nickel / methanol / 8 h / 45 - 50 °C / 2942.29 Torr / Autoclave 2: tert-butyl alcohol / 16 h / Reflux 3: 1,1'-carbonyldiimidazole / dichloromethane / 24 h / 20 - 30 °C 4: N,N-dimethyl-formamide / 120 °C 5: water; sodium t-butanolate / tetrahydrofuran / 0.5 h / 0 - 15 °C 6: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Cooling with ice 7: N,N-dimethyl-formamide / 2 h / 120 °C View Scheme
参考文献
Lee Pharma Limited; Alla, Raghu Mitra; Dubey, Ajay Kumar; Sirigiri, Aruna Kumari; Mareedu, Naga Kama Kumar
Patent: US2013/324719 A1, 2013 ;
反应条件
1: H2 / PtO2 / methanol / 3 h / 20 °C / 1471.02 Torr 2: Et3N / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
ALEMBIC LIMITED; RAMAN, Jayaraman, Venkat; RATHOD, Dhiraj; VOHRA, Irfan; CHAVAN, Mangesh; AHIRRAO, Manoj; PONNAIAH, Ravi
Patent: WO2011/77310 A1, 2011 ;
反应条件
1: hydrogen / nickel / ethanolamine; methanol / 20 °C / 3677.86 Torr
2: sodium carbonate / dichloromethane / 5 - 25 °C
View Scheme
参考文献
JUBILANT LIFE SCIENCES LIMITED; GUPTA, Ashish, Kumar; SINGH, Shishupal; PANDA, Atulya, Kumar; BISWAS, Sujay; VIR, Dharam
Patent: WO2011/114210 A2, 2011 ;
