3-氧基四氢噻吩-2-羧酸甲酯合成路线 （共 15 条）
反应条件
1: hydrogenchloride / methanol / |Inert atmosphere; |Reflux; |Large scale 2: sodium hydroxide; water / 3 h / 85 °C / |Large scale 3: N,N-diethylaniline; trichlorophosphate / 25 - 110 °C View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
参考文献
Jones, John O.; McElhinney, R. Stanley
Journal of Chemical Research, Miniprint, 1984 , # 5 p. 1501 - 1517
反应条件
sulfuryl dichloride; triethylamine
参考文献
Rossy, Phillip A.; Hoffmann, Werner; Mueller, Norbert
Journal of Organic Chemistry, 1980 , vol. 45, # 4 p. 617 - 620
反应条件
1: CH3ONa / methanol View Scheme
参考文献
Li, Zhong; Francisco, Gerardo D.; Hu, William; Labthavikul, Pornpen; Petersen, Peter J.; Severin, Anatoly; Singh, Guy; Yang, Youjun; Rasmussen, Beth A.; Lin, Yang-I; Skotnicki, Jerauld S.; Mansour, Tarek S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2591 - 2594
反应条件
MH2OH*HCl in acetonitrile 1.5 h; Heating;
参考文献
Synthetic Communications, , vol. 32, # 16 p. 2565 - 2568
