4-羟基喹啉-3-甲酸乙酯合成路线 （共 24 条）
反应条件
in o-dibenzylbenzene
参考文献
Dynamit Nobel AG
Patent: US4079058 A1, 1978 ;
反应条件
1: T=20 - 110°C; 17 h; 2: in dowtherm A T=255°C; 0.333333 h;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2005/123686 A1, 2005 ;
Location in patent: Page/Page column 75-76 ;
WO 2005/123686 A1
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
PPA; trichlorophosphate
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
ethanol; sulfuric acid
参考文献
Simpson
Journal of the Chemical Society, 1946 , p. 1035
反应条件
1: diethyl ether 2: aq.-ethanolic NaOH 3: ethanol; H2SO4 View Scheme
参考文献
Bornstein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2760
反应条件
1: aq.-ethanolic NaOH 2: ethanol; H2SO4 View Scheme
参考文献
Bornstein et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 2760
反应条件
1: POCl3; Et3N / tetrahydrofuran / 0 °C 2: magnesium bis(diisopropylamide) / diethyl ether / 0 °C 3: magnesium bis(diisopropylamide) / diethyl ether / 2 h View Scheme
参考文献
Kobayashi, Kazuhiro; Nakashima, Toshio; Mano, Masaaki; Morikawa, Osamu; Konishi, Hisatoshi
Chemistry Letters, 2001 , # 7 p. 602 - 603
反应条件
1: toluene / Heating 2: POCl3; Et3N / tetrahydrofuran / 0 °C 3: magnesium bis(diisopropylamide) / diethyl ether / 0 °C 4: magnesium bis(diisopropylamide) / diethyl ether / 2 h View Scheme
参考文献
Kobayashi, Kazuhiro; Nakashima, Toshio; Mano, Masaaki; Morikawa, Osamu; Konishi, Hisatoshi
Chemistry Letters, 2001 , # 7 p. 602 - 603
反应条件
1: magnesium bis(diisopropylamide) / diethyl ether / 0 °C 2: magnesium bis(diisopropylamide) / diethyl ether / 2 h View Scheme
参考文献
Kobayashi, Kazuhiro; Nakashima, Toshio; Mano, Masaaki; Morikawa, Osamu; Konishi, Hisatoshi
Chemistry Letters, 2001 , # 7 p. 602 - 603
