7-氟-4-羟基-3-喹啉羧酸乙酯合成路线 （共 9 条）
反应条件
in diphenylether T=250°C; Cyclization; 1 h;
参考文献
Leyva, Elisa; Monreal, Elena; Hernandez, Alma
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 7 - 10
参考文献
SENOMYS, INC.
Patent: US2011/245353 A1, 2011 ;
Title/Abstract Full Text Show Details
SENOMYX, INC.
Patent: US2012/41078 A1, 2012 ;
反应条件
1: toluene / Heating 2: diphenyl ether / 250 °C View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
1: 100 percent / 1 h / 90 - 110 °C 2: diphenyl ether / Heating View Scheme
参考文献
Leyva, Elisa; Monreal, Elena; Hernandez, Alma
Journal of Fluorine Chemistry, 1999 , vol. 94, # 1 p. 7 - 10
反应条件
water in diphenylether T=260°C; P=15001.5 Torr; 0.333333 h; microwave irradiation;
参考文献
Adams, Martina M.; Bats, Jan W.; Nikolaus, Nadja V.; Witvrouw, Myriam; Debyser, Zeger; Engels, Joachim W.
Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 978 - 990
反应条件
1: 2 N NaOH / Heating 2: diphenyl ether / 1 h / Heating 3: POCl3 / 1.17 h / 100 - 110 °C View Scheme
参考文献
De, Dibyendu; Krogstad, Frances M.; Byers, Larry D.; Krogstad, Donald J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 25 p. 4918 - 4926
反应条件
trichlorophosphate T=100°C; 0.333333 h;
参考文献
BIOLIPOX AB
Patent: WO2007/51982 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
1: trichlorophosphate 2: ammonia View Scheme
参考文献
SENOMYS, INC.
Patent: US2011/245353 A1, 2011 ;
Title/Abstract Full Text Show Details
SENOMYX, INC.
Patent: US2012/41078 A1, 2012 ;
反应条件
1: trichlorophosphate 2: ammonia View Scheme
参考文献
US2011/245353 A1, ;
US2012/41078 A1, ;
