[1,3]二氧杂环戊并[4,5-g]异喹啉合成路线 （共 28 条）
反应条件
1: 1.) NEt3, 2.) H2O / 1.) THF, 0.5 h, room temperature, 2.) CH2Cl2, 0.5 h
2: NEt3 / CHCl3 / 15 h / Ambient temperature
3: 3 M aq. HCl
4: 1.) NaH / 1.) THF, 0.5 h, reflux, 2.) 10 min, reflux
5: 27.6 percent / Bu3SnH, Et3B / toluene; hexane / Heating
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
1: 93 percent / NaH / dimethylformamide / 2 h / 25 °C
2: 81 percent / HCl / dioxane / 24 h / Heating
View Scheme
参考文献
Boger, Dale L.; Brotherton, Christine E.; Kelley, Marshall D.
Tetrahedron, 1981 , vol. 37, # 23 p. 3977 - 3980
反应条件
1: HBr / benzene / 0.17 h
2: 93 percent / NaH / dimethylformamide / 2 h / 25 °C
3: 81 percent / HCl / dioxane / 24 h / Heating
View Scheme
参考文献
Boger, Dale L.; Brotherton, Christine E.; Kelley, Marshall D.
Tetrahedron, 1981 , vol. 37, # 23 p. 3977 - 3980
参考文献
Spaeth; Polgar
Monatshefte fuer Chemie, 1929 , vol. 51, p. 199
反应条件
1: 78.5 percent / ZnI2 / 1,2-dichloro-ethane / 0.5 h / Ambient temperature
2: 97.8 percent / 5percent aq. K2CO3 / methanol / 0.25 h / Heating
3: 68.9 percent / Et3N, 4-(dimethylamino)pyridine (DMAP) / CHCl3 / 26 h / Ambient temperature
4: Bu3SnH, AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
hydrogenchloride in ethanol
参考文献
Birch,A.J. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1974 , p. 2190 - 2194
反应条件
1: NEt3 / CHCl3 / 15 h / Ambient temperature
2: 3 M aq. HCl
3: 1.) NaH / 1.) THF, 0.5 h, reflux, 2.) 10 min, reflux
4: 27.6 percent / Bu3SnH, Et3B / toluene; hexane / Heating
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
1: 99.8 percent / Et3N, 4-(dimethylamino)pyridine (DMAP) / CHCl3 / 26 h / Ambient temperature
2: Bu3SnH, AIBN / o-xylene / 2 h / Heating; other 4-subst. tetrahydroisoquinolines; var. reagents, solvents, reaction times
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
1: 68.9 percent / Et3N, 4-(dimethylamino)pyridine (DMAP) / CHCl3 / 26 h / Ambient temperature
2: Bu3SnH, AIBN / benzene / 2 h / Heating
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
反应条件
1: 99.7 percent / 5percent aq. K2CO3 / methanol / 0.5 h / Heating
2: 99.8 percent / Et3N, 4-(dimethylamino)pyridine (DMAP) / CHCl3 / 26 h / Ambient temperature
3: Bu3SnH, AIBN / o-xylene / 2 h / Heating; other 4-subst. tetrahydroisoquinolines; var. reagents, solvents, reaction times
View Scheme
参考文献
Ishizaki, Miyuki; Kurihara, Ken-ichi; Tanazawa, Eiko; Hoshino, Osamu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 101 - 110
