((2R,5s)-1-苄基吡咯烷-2,5-二基)二甲醇合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 5 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2007/81995 A2, 2007 ;
Location in patent: Page/Page column 190 ;
WO 2007/081995 A2
反应条件
1: 1) KOt-Bu / 1) THF, -78 deg C, 10 min, 2) THF, a) up to room temp., 1.5 h, b) room temp., 1.5 h 2: NaBH4 / ethanol / 15 h / Ambient temperature 3: 93 percent / AgBF4 / CH2Cl2 / 4 h / Ambient temperature 4: 1) ozone, 2) Me2S 5: LiAlH4 View Scheme
参考文献
Huby, Nicholas J. S.; Kinsman, Richard G.; Lathbury, David; Vernon, Peter G.; Gallagher, Timothy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 1 p. 145 - 155
反应条件
1: 93 percent / AgBF4 / CH2Cl2 / 4 h / Ambient temperature 2: 1) ozone, 2) Me2S 3: LiAlH4 View Scheme
参考文献
Huby, Nicholas J. S.; Kinsman, Richard G.; Lathbury, David; Vernon, Peter G.; Gallagher, Timothy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 1 p. 145 - 155
