2’-叠氮-2’-脱氧尿苷合成路线 （共 7 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; trimethylsilylazide; LiF in N,N-dimethyl-formamide T=105°C; 48 h;
参考文献
Chapuis, Hubert; Bui, Laurent; Bestel, Isabelle; Barthelemy, Philippe
Tetrahedron Letters, 2008 , vol. 49, # 48 p. 6838 - 6840
反应条件
1.1: carbonic acid diphenyl ester / N,N-dimethyl-formamide / 80 °C 1.2: 115 °C 2.1: N,N,N',N,-tetramethylethylenediamine; trimethylsilylazide; LiF / N,N-dimethyl-formamide / Heating View Scheme
参考文献
De Beeck, Marieke Op; Madder, Annemieke
Journal of the American Chemical Society, 2011 , vol. 133, # 4 p. 796 - 807
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in N,N-dimethyl acetamide; benzene 0.5 h; Heating;
参考文献
Tetrahedron Letters, , vol. 32, # 44 p. 6293 - 6296
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 1 h;
参考文献
Li, Heting; Jiang, Zhiqin; Wang, Xin; Zheng, Chao
Synthetic Communications, 2006 , vol. 36, # 14 p. 1933 - 1940
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in N,N-dimethyl acetamide; benzene 0.5 h; Heating;
参考文献
Samano; Robins
Tetrahedron Letters, 1991 , vol. 32, # 44 p. 6293 - 6296
反应条件
1.1: pyridine / 72 h / 20 °C
1.2: 95 percent / methanol / 0.17 h / 0 °C
2.1: 66 percent / hydrogen / Pd/C / methanol / 4 h / 20 °C
View Scheme
参考文献
Vasil'eva; Abramova; Ivanova; Shishkin; Sil'nikov
Russian Journal of Bioorganic Chemistry, 2004 , vol. 30, # 3 p. 234 - 242
反应条件
1: 85.7 percent / pyridine; dimethylformamide / 3 h / Ambient temperature
2: POCl3, Et3N / acetonitrile / 16 h / Ambient temperature
3: 72 percent / conc. NH4OH / dioxane / 48 h / Ambient temperature
View Scheme
参考文献
McGee; Vargeese; Zhai; Kirschenheuter; Settle; Siedem; Pieken
Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1329 - 1339
