4-氨基-3-氯-2,5,6-三氟吡啶合成路线 （共 9 条）
反应条件
ammonium hydroxide T=20°C; 5 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 1 ;
反应条件
ammonium hydroxide; zinc 24 h;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
参考文献
Banks,R.E.; Madany,I.M.
Journal of Fluorine Chemistry, 1985 , vol. 30, p. 211
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4.1.1.3, page 180 - 219
反应条件
hydrogenchloride in chloroform; acetonitrile
参考文献
Wakunaga Pharmaceuticals Co., Ltd.
Patent: US5998436 A1, 1999 ;
反应条件
1: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 40 percent / conc. H2SO4 / 18 h / 20 °C
4: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
hydrogen; triethylamine; palladium on activated charcoal in ethanol
P=2585.74 Torr; 18 h;
参考文献
Sartorelli, Alan C.; Cheng, Yung-Chi; Liu, Mao-Chin
Patent: US2004/116362 A1, 2004 ;
Location in patent: Page/Page column 11; Figure 1 ;
反应条件
1: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 40 percent / conc. H2SO4 / 18 h / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 96 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
2: 88 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 40 percent / conc. H2SO4 / 18 h / 20 °C
4: 98 percent / H2 / Raney Ni / ethanol / 2 h / 1861.73 Torr
5: 47 percent / 1 h / 100 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
