4-[3-(二甲氨基)丙氧基]苯甲醛合成路线 （共 6 条）
反应条件
18-crown-6 ether; potassium carbonate in acetone 24 h; Heating;
参考文献
NORTHWESTERN UNIVERSITY
Patent: WO2005/56499 A2, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 3 h;
参考文献
Mann; Baron; Opoku-Boahen; Johansson; Parkinson; Kelland; Neidle
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 138 - 144
参考文献
Chaudhuri, Padmaparna; Majumder, Hemanta K.; Bhattacharya, Santanu
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2536 - 2540
反应条件
sodium methylate in N,N-dimethyl-formamide 1) 50 deg C, 3 h, 2) r.t., 12 h;
参考文献
Ahn, Gang; Schifano-Faux, Nadege; Goossens, Jean-Francois; Baldeyrou, Brigitte; Couture, Axel; Grandclaudon, Pierre; Lansiaux, Amelie; Ryckebusch, Adina
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2259 - 2263
反应条件
1: 97 percent / CH2Cl2 / 24 h / 20 °C 2: 56 percent / K2CO3; 18-crown-6-ether / acetone / 24 h / Heating View Scheme
参考文献
Tajima, Keisuke; Li, Liang-Shi; Stupp, Samuel I.
Journal of the American Chemical Society, 2006 , vol. 128, # 16 p. 5488 - 5495
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C View Scheme
参考文献
Manohar, Sunny; Khan, Shabana I.; Kandi, Shamseer Kulangara; Raj, Kranthi; Sun, Guojing; Yang, Xiaochuan; Calderon Molina, Angie D.; Ni, Nanting; Wang, Binghe; Rawat, Diwan S.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 112 - 116
